쉐도잉 연습: SVINutes: Pediatric Cerebrovascular Disease: Current Strategies, Future Directions - 영상으로 영어 말하기 배우기

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Hello everyone, my name is Alhamza Albiadi, an Associate Professor of Neurology and Neurosurgery at the University of Pittsburgh School of Medicine.
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I'm a Stroke Specialist and Neurointerventionist,
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serve as the Director of Pediatric Neuroendrovascular Surgery and Surgical Co-Director of the Neurovascular Center of Excellence at Children's Hospital UPMC.
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Today I'll be highlighting key concepts in pediatric cerebrovascular disease, current strategies, and where the field is heading.
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This is an educational discussion and reflects my clinical judgment and experience.
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So, the key principle is simple but critical.
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Pediatric cerebrovascular disease is not adult in smaller bodies.
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The causes are fundamentally different as children are dominated by arteriopathies like moya moya cardiac
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and embolic sources genetic syndromes
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and vascular malformations hemorrhagic strokes makes up almost half of pediatric
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cases compared to only 10 to 15 in the adults
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and their symptoms are subtle often non-focal
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or seizure-like leading to diagnostic delays everything we do must focus not just on acute survival but on long-term neurodevelopmental trajectory.
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In the acute ischemic setting, the biggest challenge we face is the recognition and time to diagnosis.
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Dedicated pediatric stroke alerts and multidisciplinary mobilization dramatically improve the accuracy and workflow.
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MRI with DWI and MRA remains our definitive tool to diagnosis of ischemia and assessing vessel status.
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IV thrombolysis remains off-label, used selectively in adolescents who meet adult criteria at expert centers.
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Endovascular thrombectomy is increasingly used for large vessel occlusion, with a growing evidence-based, showing feasibility and safety,
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even though the data are largely extrapolated from adults.
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Prevention must be tailored to etiology.
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For instance, non-Moyomoy arteriopathy typically responds well to antiplatelet therapy.
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Moyomoy disease, however, is unique.
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Surgical revascularization with indirect bypass, EDAS, remains the most effective long-term neovascularization strategy.
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For sickle cell disease, chronic transfusions are still the standard guided by TCD velocities.
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And in children with cardiac disease or thrombophilias, long-term anticoagulation is often necessary.
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Remember, each child requires individualized planning and multidisciplinary input.
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Pediatric AVMs behave differently.
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They are dynamic, can recruit new feeders, and can carry high lifetime risk of hemorrhage.
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After rupture, the first phase is damage control, stabilizing the child, managing ICP, and addressing the hematoma.
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Definitive AVM treatment is usually delayed until it's safe.
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Our curative tools include microsurgery, which remains the gold standard for accessible lesions,
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stereotactic radiosurgery for deep inaccessible AVMs, and targeted endovascular embolization as an adjunct.
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When performing pre-operative embolization, precision is everything.
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The key goal is to reduce the nitis size without compromising the venous drainage or normal perforators.
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Vanum-gallon malformation is the benchmark of our neuroendovascular subspecialty.
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These babies present critically with neonatal heart failure and pulmonary hypertension.
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Older infants, however, may present with microcephaly or hydrocephalus.
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Our treatment strategy is stage endovascular embolization, a controlled and gradual shunt reduction.
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The goal is to relieve the life-threatening venous hypertension and allowing the cardiovascular system to recover.
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Success relies on ultra-fine microcaptors, precise liquid embolics, and focal coiling of arteriovenous chuntings for controlled obliterations.
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Our pediatric neuroendrovascular field also focuses on targeted therapeutics and functional testing.
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Intraarterial chemotherapy for retinoblastoma, usually delivered through the ophthalmic artery, with remarkable vision-saving outcomes.
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And for functional localization, the wider test still plays an important role in complex epilepsy or tumor cases,
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helping map the language and memory dominance to avoid postoperative deficits.
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Effective pediatric cerebrovascular care depends on a robust team.
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Neurointervention, neurosurgery, pediatric vascular neurology, and pediatric critical care are the core of this team.
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Supporting roles from cardiology, hematology,
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genetics, rehab, and social work are essential in guiding etiology and long-term recovery.
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These children needs both ongoing imaging surveillance and lifelong functional monitoring.
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The future of pediatric neurovascular disease is precision-based.
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Genomics, enhanced by endoluminal and liquid biopsy techniques,
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are beginning to identify actionable mutations that might guide targeted non-surgical drug therapeutics.
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Advanced imaging, such as vessel wall imaging, and 4D flow MRI is helping us visualize not just the anatomy,
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but the underlying vascular physiology and hemodynamics that truly drive disease behavior.
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As we look ahead, success isn't just recinalization or nidus obliteration.
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It's restoring normal neurodevelopmental growth and function over lifetime.
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Our mission is to protect the developing brain through multidisciplinary excellence and collaborative research.
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Thank you for your time.
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I look forward to ongoing discussions and collaborations.
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Please feel free to reach out at any time.
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Thank you you

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