Pratique du Shadowing: Ozempic Explained Like You're 5 - Apprendre l'anglais à l'oral avec la vidéo
Création de la leçon...
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This is Ozempic, the drug that can make people lose this much weight with just one injection a week.
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But how does it actually work?
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Is it truly safe?
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And what happens when people stop taking it?
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To answer these questions, we first need to understand why losing weight is so difficult.
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The world has a fat problem, a massive, global, decades -long problem.
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More than a billion adults are now classified as obese, a number that has tripled since 1975.
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So the solution should be simple, right?
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Eat less?
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Move more?
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Problem solved?
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No. Because the moment you start eating less, your body says, we are under attack.
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Release the hunger.
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Your metabolism slows down.
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Your body starts treating every calorie like it's the last helicopter out of Saigon.
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Which is why so many people lose weight and then gain it all back.
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For decades, scientists knew the body was fighting back.
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They just couldn't figure out how to turn that signal off.
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Then the answer came from the last place anyone expected.
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A lizard.
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Introducing Dr. John Eng.
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Eng was an endocrinologist, a doctor who treats hormone -related problems in the body at a VA hospital in the Bronx with a very unusual interest.
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Venom.
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More specifically, the venom of the Gila monster.
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A large, slow, deeply unfortunate -looking lizard from the American Southwest that looks like it was assembled from leftover parts.
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John.
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What are you doing?
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This thing barely eats.
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Sometimes only a few times a year.
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And yet, somehow, its body stays stable.
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Maybe that is just what it does.
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Ain't no way.
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Something in that saliva is keeping it alive.
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So Eng studies the lizard's venom.
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And inside it, he finds something remarkable.
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A compound that behaves a lot like a human hormone called GLP -1.
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Now GLP -1 is basically the body's meal signal.
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You eat.
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Your gut sends a message to your brain.
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Food arrived.
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You can stop eating now.
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Then it sends another message to your pancreas.
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Sugar incoming.
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Release insulin.
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When that signal works properly, the body handles food without much drama.
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When it does not, everything starts getting messier.
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Appetite?
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Insulin response?
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Blood sugar?
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Weight?
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The whole system begins slipping out of balance.
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And Eng realizes something huge.
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What if you could replace that failing signal?
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That idea eventually leads to the first GLP -1 drug.
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For the first time, medicine is not just treating the consequences of metabolic disease.
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It is trying to restore one of the signals behind it.
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But there is one problem.
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The drug is clunky.
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Patients need to inject it twice a day.
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The effect fades quickly, so most of the world shrugs and moves on.
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Except for one company watching from Denmark.
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They look at the same drug everyone else dismisses and see something different.
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Introducing Novo Nordisk.
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They are a Danish company that has spent 50 years as the backbone of diabetic care.
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Insulin is their main solution.
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But it has limits.
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Insulin helps manage blood sugar and keep patients alive.
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Yet it does not fix the deeper signaling problem underneath where GLP -1 might.
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So Novo sets itself a brutal goal.
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Let's make it last for a week.
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That is the target.
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The molecule dissolves in minutes.
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Two minutes.
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How do you build a weekly drug out of something that dissolves quickly?
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That is the job.
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And this is where the nightmare begins.
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The moment natural GLP -1 enters the bloodstream, the body breaks it down almost immediately.
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So they change the molecular structure.
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Tweaking it for stability?
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It loses power.
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Making it more powerful, the body destroys it faster.
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Again and again and again.
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216 versions.
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None good enough.
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But now it's a good enough time for a quick ad break.
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You know what's weird?
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I'll spend three hours researching whether a $20 gadget is worth buying, but the moment I need to book a doctor's appointment, suddenly my brain goes, eh, tomorrow.
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Because then you have to call, wait on hold, play phone tag, and by the time someone finally answers, the next appointment is sometime after the heat death of the universe.
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That's why I've started using ZocDoc.
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It lets you search and compare local in -network doctors, read reviews from real patients, check actual appointment availability, and book online in just a few clicks.
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Appointments are often available within 24 to 72 hours, sometimes even the same day.
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And it's completely free to use.
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So if you've been putting off making that appointment like I used to.
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Click the link in the description or head to zocdoc .com slash crayoncapital.
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Seriously, it's a small click that makes taking care of your health a whole lot easier?
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Okay, back to Novo.
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The costs keep growing and the confidence shrinking.
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The problem is starting to look unsolvable.
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But then, what if we attach a fatty acid chain to it?
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A fatty acid?
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Why?
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Okay, think of the bloodstream like a nightclub.
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The body's enzymes are the bouncers.
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Anything foreign gets spotted and thrown out.
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Our drug?
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Kicked out in minutes.
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But albumin is a protein that naturally lives in the blood.
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The VIP who's never questioned?
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And the only thing that gets albumin's attention?
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Fatty acids.
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It's basically albumin's magnet.
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So if we attach a fatty acid to our drug, albumin pulls it in like a plus one.
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Suddenly it's not a stranger anymore.
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It's rolling in with the VIP.
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Bouncers wave it through.
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It stays in the system for a week.
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At last, on the 217 attempts, they have it.
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A lab -engineered version of the body's own signal, built to last 7 days instead of minutes.
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In 2017, the FDA approved it for type 2 diabetes.
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And they name it, Ozempic.
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It is a quiet launch.
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No headlines.
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Just another diabetes drug entering a crowded market.
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But doctors start noticing something strange.
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Did you change these patients' diets?
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Tell them to exercise or anything?
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Hmm, I don't think I did.
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Why, is something wrong?
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No, it's just they lost weight.
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Like, all of them.
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For most companies, this would be the dream.
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A diabetes drug that also makes people lose weight?
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That is a jackpot, not a side effect.
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But inside Novo, nobody is celebrating too loudly yet.
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Because weight loss drugs had a history.
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A very ugly one.
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The results were disappointing, dangerous, or both.
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Fen -Fen pulled in 1997?
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Meridia pulled in 2010?
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By the 2010s, much of medicine had reached an uncomfortable conclusion.
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Maybe obesity was too complicated for a drug to solve.
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But Novo doesn't flinch.
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They launch a major clinical trial to answer one question.
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Can this drug cause major weight loss in people who do not even have diabetes?
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Hi, I'm calling from Novo.
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I just wanted to check if the trial data has been reviewed yet.
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Yes.
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We finished going through it this morning.
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Patients lost an average of 15 % of their body weight.
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Some were closer to 20.
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Sorry, what?
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15 %?
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Average.
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Across the trial.
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Before this, the best FDA -approved weight loss drugs usually delivered around 5 to 8 percent weight loss on average.
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That was considered strong.
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This is not a slightly better obesity drug.
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This is in a completely different league.
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A weekly injection was now producing numbers people used to associate with surgery.
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So researchers and regulators check the data again and again.
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The methodology holds, the results hold.
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The weight loss is real.
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So by 2021, the FDA approved a higher dose version specifically for obesity, WEGAV.
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And just like that, the drug splits into two identities.
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Ozempic for diabetes, the stronger dose for weight loss.
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That is when the story leaves medicine and enters culture.
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Doctors start getting flooded with questions.
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Patients start asking for it by name
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because suddenly celebrities are looking smaller influencers are whispering about it and search traffic is exploding
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ozembek goes viral demand surges sales explode where by 2024 the
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drugs generated 26 billion dollars in revenue novo nordisk becomes one of the biggest pharmaceutical stories on earth
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But there is one problem.
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They cannot make enough.
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In 2022, the FDA placed Ozempic and Wegevee on its shortage list.
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And this is where the story gets ugly.
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Good afternoon.
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Welcome to Crayon Pharmacy?
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Picking up a prescription?
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Yes, Ozempic.
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I see it here.
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Just so you know, your insurance didn't cover it, so this would be out of pocket today.
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How much?
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Total is $1 ,200.
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Fine.
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Sorry, you have Ozempic?
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I'm here for another prescription.
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But I've been trying to get a refill for weeks.
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I see your refill request.
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Your insurance covered order is still pending.
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We're waiting on allocated stock for covered prescriptions.
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But there's one right there.
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This one has already been processed as a cash pay prescription, so if I can pay cash, I can get it today?
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I have type 2 diabetes.
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I've been on this for two years.
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I really need this.
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Is there a problem?
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You're all set.
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Thank you for waiting.
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Your medication and receipt are in the bag.
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Have a wonderful day.
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regarding your situation we can fill the temporary medication your doctor
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sent in you've got to be kidding me I'm sorry for the inconvenience
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but until your insurance covered refill clears there's nothing I can release today except the temporary medication
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and that is the dangerous part
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if the official system will not give people the drug someone else in the gray market will.
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Clinics offering the alternatives at a fraction of the market price.
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$200 a month instead of $1 ,200.
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No wait list.
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No insurance battle.
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A quick online form and a vial arrives at your door.
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It sounded perfect for desperate patients.
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Until it wasn't.
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By 2023, Faco Zempic has entered the American drug supply chain, manufactured to look real, distributed through channels that bypass safety checks,
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sold into a market desperate for the miracle.
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Some patients received the wrong dose or the wrong substance, leading to some being hospitalized.
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But even the real drug wasn't perfect.
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Nausea.
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Vomiting.
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Sometimes bad enough that patients quit in the first month.
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Doctors started noticing muscle loss alongside the fat.
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And the worst part?
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I stopped taking it six months ago.
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I've gained almost everything back.
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That's not uncommon.
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So is this a cure or a subscription?
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The drug didn't cure anything.
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It managed it.
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Stopped paying.
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The hunger comes back.
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The body remembers.
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But we had been here before.
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Novo Nordisk failed 216 attempts.
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Every dead end eventually wasn't.
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So the scientists went back to work.
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Next generation drugs already in trials, Preserving muscle, lasting a month instead of a week.
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Showing signals in alcohol cravings, opioid addiction, even brain disease.
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What started in a lizard's venom was turning out to be something much larger.
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By 2025, the chaos had settled.
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Supply caught up.
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The gray market collapsed.
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And quietly, without anyone declaring it, the conversation had moved on.
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If hunger could be rewritten, what else could?
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As Brian Johnson said, we might be the first generation, that doesn't die.
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Vocabulaire et conseils d’expression pour cette leçon
Cette vidéo contient 242 phrases et 1820 mots à répéter en shadowing. La partie parlée dure 12:28. Le locuteur parle à un rythme régulier d’environ 146 mots par minute, confortable pour le shadowing. Seuls 79 % des mots font partie des 3 000 mots les plus courants en anglais, le vocabulaire est donc exigeant.
Vocabulaire clé de cette vidéo
15 mots de la vidéo à retenir, avec leur prononciation et leur sens :
| Mot | Prononciation | Sens |
|---|---|---|
| diabetes nom | /ˌdaɪəˈbiːtiːz/ | diabète |
| acid nom | /ˈæsɪd/ | acide |
| prescription nom | /pɹəˈskɹɪp.ʃən/ | ordonnance |
| insulin nom | /ˈɪnsəlɪn/ | insuline |
| venom nom | /ˈvɛnəm/ | venin |
| dose nom | /ˈdəʊ̯s/ | dose |
| medication nom | /mɛdɪˈkeɪʃən/ | médication |
| hunger nom | /ˈhʌŋɡɚ/ | faim |
| approve verbe | /əˈpɹuːv/ | approuver |
| obesity nom | /ə(ʊ)ˈbiːsɪti/ | obésité |
| temporary adjectif | /ˈtɛmp(əˌɹ)ɛɹi/ | temporaire, provisoire |
| gray adjectif | /ɡɹeɪ/ | gris |
| muscle nom | /ˈmʌs.əl/ | muscle |
| solve verbe | /sɒlv/ | résoudre, régler |
| ugly adjectif | /ˈʌɡli/ | laid, moche |
Les verbes à particule que vous entendrez
| Mot | Prononciation | Sens |
|---|---|---|
| come back verbe | revenir | |
| fight back verbe | /faɪt bæk/ | contre-attaquer |
| figure out verbe | cerner | |
| go through verbe | traverser | |
| pick up verbe | soulever | |
| put off verbe | ajourner | |
| slow down verbe | ralentir, décélérer |
Prononciation à surveiller
Le locuteur utilise 22 contractions et formes réduites, comme I've, I'm, wasn't. Prononcez-les sous leur forme courte, telles que vous les entendez.
- Les sons « th »: underneath /ˌʌndɚˈniθ/, methodology /ˌmɛθ.əˈdɑ.lə.d͡ʒi/
- Les sons « sh » et « zh »: prescription /pɹəˈskɹɪp.ʃən/, medication /mɛdɪˈkeɪʃən/, injection /ɪnˈd͡ʒɛk.ʃən/, unusual /ʌnˈjuːʒ(u)əl/, conclusion /kənˈkluːʒən/
- Mots longs — placez bien l’accent: medication /mɛdɪˈkeɪʃən/, obesity /ə(ʊ)ˈbiːsɪti/, temporary /ˈtɛmp(əˌɹ)ɛɹi/, naturally /ˈnæt͡ʃ.(ə.)ɹə.li/, complicated /ˈkɑm.plɪˌkeɪ.tɪd/
Comment s’entraîner avec cette vidéo
- Écoutez la vidéo en entier une fois sans parler et notez les mots que vous ne connaissez pas.
- Répétez phrase par phrase à vitesse normale, en reprenant chacune jusqu’à ce que votre rythme corresponde à celui du locuteur.
- Enregistrez-vous et comparez avec l’original, en faisant attention à des mots comme diabetes, acid, prescription.
La grammaire de cette vidéo
Les structures que le locuteur utilise le plus, avec les mots exacts de la vidéo :
| Structure | Dans la vidéo |
|---|---|
| Present perfect continu have/has been + -ing — une action commencée avant et toujours en cours | you've been putting · I've been trying |
| Present perfect have/has + participe passé — une action passée qui compte encore maintenant | has tripled · has spent · I've started |
| Voix passive be + participe passé — l’accent est mis sur ce qui arrive, pas sur qui le fait | are now classified · was assembled · has been reviewed |
Qu'est-ce que la technique du Shadowing ?
Le Shadowing est une technique d'apprentissage des langues fondée sur la science, développée à l'origine pour la formation des interprètes professionnels. Le principe est simple mais puissant : vous écoutez de l'anglais natif et le répétez immédiatement à voix haute — comme une ombre suivant le locuteur avec un décalage de 1 à 2 secondes. Les recherches montrent une amélioration significative de la précision de la prononciation, de l'intonation, du rythme, des liaisons, de la compréhension orale et de la fluidité.