Shadowing Practice: Ozempic Explained Like You're 5 - Learn English Speaking with Video
Ders oluşturuluyor...
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This is Ozempic, the drug that can make people lose this much weight with just one injection a week.
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But how does it actually work?
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Is it truly safe?
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And what happens when people stop taking it?
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To answer these questions, we first need to understand why losing weight is so difficult.
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The world has a fat problem, a massive, global, decades -long problem.
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More than a billion adults are now classified as obese, a number that has tripled since 1975.
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So the solution should be simple, right?
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Eat less?
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Move more?
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Problem solved?
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No. Because the moment you start eating less, your body says, we are under attack.
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Release the hunger.
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Your metabolism slows down.
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Your body starts treating every calorie like it's the last helicopter out of Saigon.
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Which is why so many people lose weight and then gain it all back.
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For decades, scientists knew the body was fighting back.
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They just couldn't figure out how to turn that signal off.
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Then the answer came from the last place anyone expected.
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A lizard.
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Introducing Dr. John Eng.
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Eng was an endocrinologist, a doctor who treats hormone -related problems in the body at a VA hospital in the Bronx with a very unusual interest.
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Venom.
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More specifically, the venom of the Gila monster.
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A large, slow, deeply unfortunate -looking lizard from the American Southwest that looks like it was assembled from leftover parts.
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John.
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What are you doing?
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This thing barely eats.
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Sometimes only a few times a year.
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And yet, somehow, its body stays stable.
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Maybe that is just what it does.
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Ain't no way.
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Something in that saliva is keeping it alive.
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So Eng studies the lizard's venom.
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And inside it, he finds something remarkable.
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A compound that behaves a lot like a human hormone called GLP -1.
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Now GLP -1 is basically the body's meal signal.
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You eat.
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Your gut sends a message to your brain.
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Food arrived.
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You can stop eating now.
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Then it sends another message to your pancreas.
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Sugar incoming.
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Release insulin.
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When that signal works properly, the body handles food without much drama.
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When it does not, everything starts getting messier.
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Appetite?
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Insulin response?
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Blood sugar?
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Weight?
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The whole system begins slipping out of balance.
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And Eng realizes something huge.
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What if you could replace that failing signal?
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That idea eventually leads to the first GLP -1 drug.
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For the first time, medicine is not just treating the consequences of metabolic disease.
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It is trying to restore one of the signals behind it.
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But there is one problem.
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The drug is clunky.
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Patients need to inject it twice a day.
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The effect fades quickly, so most of the world shrugs and moves on.
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Except for one company watching from Denmark.
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They look at the same drug everyone else dismisses and see something different.
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Introducing Novo Nordisk.
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They are a Danish company that has spent 50 years as the backbone of diabetic care.
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Insulin is their main solution.
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But it has limits.
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Insulin helps manage blood sugar and keep patients alive.
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Yet it does not fix the deeper signaling problem underneath where GLP -1 might.
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So Novo sets itself a brutal goal.
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Let's make it last for a week.
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That is the target.
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The molecule dissolves in minutes.
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Two minutes.
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How do you build a weekly drug out of something that dissolves quickly?
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That is the job.
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And this is where the nightmare begins.
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The moment natural GLP -1 enters the bloodstream, the body breaks it down almost immediately.
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So they change the molecular structure.
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Tweaking it for stability?
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It loses power.
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Making it more powerful, the body destroys it faster.
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Again and again and again.
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216 versions.
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None good enough.
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But now it's a good enough time for a quick ad break.
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You know what's weird?
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I'll spend three hours researching whether a $20 gadget is worth buying, but the moment I need to book a doctor's appointment, suddenly my brain goes, eh, tomorrow.
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Because then you have to call, wait on hold, play phone tag, and by the time someone finally answers, the next appointment is sometime after the heat death of the universe.
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That's why I've started using ZocDoc.
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It lets you search and compare local in -network doctors, read reviews from real patients, check actual appointment availability, and book online in just a few clicks.
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Appointments are often available within 24 to 72 hours, sometimes even the same day.
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And it's completely free to use.
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So if you've been putting off making that appointment like I used to.
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Click the link in the description or head to zocdoc .com slash crayoncapital.
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Seriously, it's a small click that makes taking care of your health a whole lot easier?
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Okay, back to Novo.
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The costs keep growing and the confidence shrinking.
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The problem is starting to look unsolvable.
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But then, what if we attach a fatty acid chain to it?
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A fatty acid?
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Why?
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Okay, think of the bloodstream like a nightclub.
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The body's enzymes are the bouncers.
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Anything foreign gets spotted and thrown out.
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Our drug?
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Kicked out in minutes.
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But albumin is a protein that naturally lives in the blood.
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The VIP who's never questioned?
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And the only thing that gets albumin's attention?
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Fatty acids.
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It's basically albumin's magnet.
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So if we attach a fatty acid to our drug, albumin pulls it in like a plus one.
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Suddenly it's not a stranger anymore.
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It's rolling in with the VIP.
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Bouncers wave it through.
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It stays in the system for a week.
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At last, on the 217 attempts, they have it.
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A lab -engineered version of the body's own signal, built to last 7 days instead of minutes.
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In 2017, the FDA approved it for type 2 diabetes.
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And they name it, Ozempic.
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It is a quiet launch.
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No headlines.
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Just another diabetes drug entering a crowded market.
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But doctors start noticing something strange.
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Did you change these patients' diets?
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Tell them to exercise or anything?
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Hmm, I don't think I did.
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Why, is something wrong?
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No, it's just they lost weight.
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Like, all of them.
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For most companies, this would be the dream.
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A diabetes drug that also makes people lose weight?
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That is a jackpot, not a side effect.
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But inside Novo, nobody is celebrating too loudly yet.
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Because weight loss drugs had a history.
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A very ugly one.
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The results were disappointing, dangerous, or both.
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Fen -Fen pulled in 1997?
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Meridia pulled in 2010?
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By the 2010s, much of medicine had reached an uncomfortable conclusion.
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Maybe obesity was too complicated for a drug to solve.
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But Novo doesn't flinch.
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They launch a major clinical trial to answer one question.
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Can this drug cause major weight loss in people who do not even have diabetes?
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Hi, I'm calling from Novo.
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I just wanted to check if the trial data has been reviewed yet.
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Yes.
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We finished going through it this morning.
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Patients lost an average of 15 % of their body weight.
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Some were closer to 20.
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Sorry, what?
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15 %?
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Average.
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Across the trial.
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Before this, the best FDA -approved weight loss drugs usually delivered around 5 to 8 percent weight loss on average.
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That was considered strong.
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This is not a slightly better obesity drug.
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This is in a completely different league.
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A weekly injection was now producing numbers people used to associate with surgery.
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So researchers and regulators check the data again and again.
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The methodology holds, the results hold.
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The weight loss is real.
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So by 2021, the FDA approved a higher dose version specifically for obesity, WEGAV.
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And just like that, the drug splits into two identities.
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Ozempic for diabetes, the stronger dose for weight loss.
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That is when the story leaves medicine and enters culture.
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Doctors start getting flooded with questions.
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Patients start asking for it by name
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because suddenly celebrities are looking smaller influencers are whispering about it and search traffic is exploding
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ozembek goes viral demand surges sales explode where by 2024 the
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drugs generated 26 billion dollars in revenue novo nordisk becomes one of the biggest pharmaceutical stories on earth
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But there is one problem.
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They cannot make enough.
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In 2022, the FDA placed Ozempic and Wegevee on its shortage list.
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And this is where the story gets ugly.
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Good afternoon.
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Welcome to Crayon Pharmacy?
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Picking up a prescription?
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Yes, Ozempic.
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I see it here.
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Just so you know, your insurance didn't cover it, so this would be out of pocket today.
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How much?
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Total is $1 ,200.
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Fine.
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Sorry, you have Ozempic?
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I'm here for another prescription.
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But I've been trying to get a refill for weeks.
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I see your refill request.
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Your insurance covered order is still pending.
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We're waiting on allocated stock for covered prescriptions.
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But there's one right there.
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This one has already been processed as a cash pay prescription, so if I can pay cash, I can get it today?
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I have type 2 diabetes.
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I've been on this for two years.
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I really need this.
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Is there a problem?
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You're all set.
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Thank you for waiting.
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Your medication and receipt are in the bag.
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Have a wonderful day.
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regarding your situation we can fill the temporary medication your doctor
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sent in you've got to be kidding me I'm sorry for the inconvenience
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but until your insurance covered refill clears there's nothing I can release today except the temporary medication
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and that is the dangerous part
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if the official system will not give people the drug someone else in the gray market will.
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Clinics offering the alternatives at a fraction of the market price.
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$200 a month instead of $1 ,200.
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No wait list.
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No insurance battle.
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A quick online form and a vial arrives at your door.
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It sounded perfect for desperate patients.
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Until it wasn't.
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By 2023, Faco Zempic has entered the American drug supply chain, manufactured to look real, distributed through channels that bypass safety checks,
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sold into a market desperate for the miracle.
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Some patients received the wrong dose or the wrong substance, leading to some being hospitalized.
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But even the real drug wasn't perfect.
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Nausea.
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Vomiting.
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Sometimes bad enough that patients quit in the first month.
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Doctors started noticing muscle loss alongside the fat.
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And the worst part?
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I stopped taking it six months ago.
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I've gained almost everything back.
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That's not uncommon.
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So is this a cure or a subscription?
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The drug didn't cure anything.
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It managed it.
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Stopped paying.
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The hunger comes back.
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The body remembers.
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But we had been here before.
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Novo Nordisk failed 216 attempts.
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Every dead end eventually wasn't.
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So the scientists went back to work.
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Next generation drugs already in trials, Preserving muscle, lasting a month instead of a week.
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Showing signals in alcohol cravings, opioid addiction, even brain disease.
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What started in a lizard's venom was turning out to be something much larger.
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By 2025, the chaos had settled.
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Supply caught up.
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The gray market collapsed.
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And quietly, without anyone declaring it, the conversation had moved on.
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If hunger could be rewritten, what else could?
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As Brian Johnson said, we might be the first generation, that doesn't die.
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Bu dersin kelimeleri ve konuşma notları
Bu videoda gölgeleme çalışması için 242 cümle ve 1820 kelime var. Konuşma bölümü 12:28 sürüyor. Konuşmacı dakikada yaklaşık 146 kelimelik dengeli bir hızla konuşuyor; gölgeleme için rahat bir tempo. Kelimelerin yalnızca %79’i İngilizcede en sık kullanılan 3.000 kelime arasında, bu yüzden kelime dağarcığı zorlayıcı.
Bu videodaki önemli kelimeler
Videodan öğrenmeye değer 15 kelime, telaffuzu ve anlamıyla:
| Kelime | Telaffuz | Anlam |
|---|---|---|
| diabetes isim | /ˌdaɪəˈbiːtiːz/ | diyabet, şeker hastalığı |
| acid isim | /ˈæsɪd/ | asit |
| prescription isim | /pɹəˈskɹɪp.ʃən/ | reçete |
| insulin isim | /ˈɪnsəlɪn/ | insülin |
| venom isim | /ˈvɛnəm/ | zehir, ağı |
| dose isim | /ˈdəʊ̯s/ | doz |
| hunger isim | /ˈhʌŋɡɚ/ | açlık, aç |
| approve fiil | /əˈpɹuːv/ | onaylamak |
| obesity isim | /ə(ʊ)ˈbiːsɪti/ | obezite |
| temporary sıfat | /ˈtɛmp(əˌɹ)ɛɹi/ | geçici |
| gray sıfat | /ɡɹeɪ/ | gri, boz |
| muscle isim | /ˈmʌs.əl/ | kas, adale |
| solve fiil | /sɒlv/ | çözmek, halletmek |
| ugly sıfat | /ˈʌɡli/ | çirkin |
| introduce fiil | /ˌɪntɹəˈdus/ | tanıştırmak |
Duyacağınız deyimsel fiiller
| Kelime | Anlam |
|---|---|
| figure out fiil | açığa çıkarmak |
| slow down fiil | yavaşlamak |
Dikkat edilecek telaffuzlar
Konuşmacı I've, I'm, wasn't gibi kısaltılmış biçimleri 22 kez kullanıyor. Bunları duyduğunuz gibi kısa söyleyin.
- “th” sesleri: underneath /ˌʌndɚˈniθ/, methodology /ˌmɛθ.əˈdɑ.lə.d͡ʒi/
- “sh” ve “zh” sesleri: prescription /pɹəˈskɹɪp.ʃən/, medication /mɛdɪˈkeɪʃən/, injection /ɪnˈd͡ʒɛk.ʃən/, unusual /ʌnˈjuːʒ(u)əl/, conclusion /kənˈkluːʒən/
- Uzun kelimeler — vurguyu doğru yere koyun: medication /mɛdɪˈkeɪʃən/, obesity /ə(ʊ)ˈbiːsɪti/, temporary /ˈtɛmp(əˌɹ)ɛɹi/, naturally /ˈnæt͡ʃ.(ə.)ɹə.li/, complicated /ˈkɑm.plɪˌkeɪ.tɪd/
Bu videoyla nasıl çalışılır
- Videonun tamamını konuşmadan bir kez dinleyin ve bilmediğiniz kelimeleri not edin.
- Normal hızda cümle cümle tekrar edin; ritminiz konuşmacıyla aynı olana kadar her cümleyi yineleyin.
- Kendinizi kaydedin ve orijinaliyle karşılaştırın; diabetes, acid, prescription gibi kelimelere özellikle dikkat edin.
Bu videodaki dil bilgisi
Konuşmacının en çok kullandığı yapılar, videodaki sözcüklerin aynısıyla:
| Yapı | Videoda |
|---|---|
| Present perfect continuous have/has been + -ing — önceden başlayıp hâlâ süren bir eylem | you've been putting · I've been trying |
| Present perfect have/has + fiilin üçüncü hâli — geçmişte olan ama şimdi de önemli olan bir eylem | has tripled · has spent · I've started |
| Edilgen yapı be + fiilin üçüncü hâli — kimin yaptığı değil, ne olduğu önemli | are now classified · was assembled · has been reviewed |
Gölgeleme Tekniği Nedir?
Gölgeleme, başlangıçta profesyonel tercüman eğitimi için geliştirilen ve çok dilli Dr. Alexander Arguelles tarafından popüler hale getirilen, bilim destekli bir dil öğrenme tekniğidir. Yöntem basit ama güçlüdür: ana dili İngilizce olan bir sesi dinler ve hemen yüksek sesle tekrar edersiniz — konuşmacıyı 1-2 saniye gecikmeyle takip eden bir gölge gibi. Pasif dinleme veya dilbilgisi alıştırmalarının aksine, gölgeleme beyninizi ve ağız kaslarınızı gerçek konuşma kalıplarını eşzamanlı olarak işlemeye ve yeniden üretmeye zorlar. Araştırmalar, telaffuz doğruluğu, tonlama, ritim, bağlı konuşma, dinleme anlama ve konuşma akıcılığını önemli ölçüde geliştirdiğini göstermektedir — bu da onu IELTS Konuşma hazırlığı ve gerçek dünya İngilizce iletişimi için en etkili yöntemlerden biri yapar.