تدريب Shadowing: The 3 best predictors of how well you’ll age - Juulia Jylhävä - تعلم التحدث بالإنجليزية مع YouTube

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The The The The The The The If you want to learn a fish's age,
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The The The The The The The If you want to learn a fish's age,
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simply take one of its scales and count the number of bands radiating from its center.
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For trees, you can count their rings.
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For narwhals, their tusk layers.
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And for blue whales, their layers of earwax.
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When it comes to humans,
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scientists have yet to find any visible traits that mark our age with anywhere near the same specificity.
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But in the past few decades,
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they've discovered small, invisible markers hidden within the body that do change over time.
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And they may hold even more information about our health, history, and future.
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The first of these markers was discovered in the 1990s.
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Telomeres are repetitive sequences at the ends of DNA strands that protect chromosomes from fusing together.
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However, each time a cell divides,
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part of the telomere is cut off.
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These small losses can add up over time,
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and once telomeres get too short,
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cells lose their ability to replicate and eventually die.
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This gradual shrinking process led scientists to identify telomere length as a promising,
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albeit imperfect, marker of aging.
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As technology has advanced, scientists learned how to detect even more discrete changes to DNA,
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like the addition of individual molecular tags called methyl groups.
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This DNA methylation can control gene expression,
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including switching genes on and off.
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It can occur rapidly and frequently,
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allowing cells to respond to different situations and perform normal functions.
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Yet researchers noticed that at certain sites in the genome,
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methylation levels tend to change more gradually and predictably as we age.
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The reason for this is still unknown,
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but these changes may be associated with stress or caused by random errors during DNA replication.
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By measuring DNA methylation patterns from hundreds or thousands of these sites,
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scientists have developed what they call epigenetic clocks as another way to measure aging.
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A third way our bodies change over time is through inflammation.
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Proteins that are important components of the immune system generally increase when we get sick,
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then decrease again once our body has recovered.
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But as we get older,
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their baseline levels rise, resulting in chronic, low-level inflammation.
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This process is called inflammation.
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Scientists are still unsure why it occurs,
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but it could be due to repeated encounters with pathogens and other stresses.
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Another explanation could be the process of cellular senescence.
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When cells get old and stop dividing, they secrete inflammatory proteins.
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And by measuring the level of these proteins,
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scientists have developed yet another clock that can accurately measure aging aging.
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While all three of these markers are great additions to the age estimation toolbox,
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they don't perfectly correlate with chronological age.
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Instead, they're best at estimating something called biological age.
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Biological age is a measure of how well your body is functioning,
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how much damage your cells and organs have accumulated,
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and your overall risk for certain health problems.
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Unlike chronological clocks, biological clocks tick at different rates for for different people due to genetic differences,
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as well as health, stress,
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and many other environmental factors.
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And different tissues and organs within the body may even biologically age at different speeds.
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In many ways, these clocks are still a work in progress.
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For example, most experts recommend against personalized biological age testing.
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While these tests are commercially available,
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the value and accuracy of these measurements remain unclear.
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Currently, these tools work best at the population level,
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when data from many individuals are analysed.
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However, many scientists hope to change this in the future,
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as accurately tracking this information could revolutionise personalised healthcare.
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For example, one day, a person's accelerated biological age might help doctors detect an unknown health condition much earlier.
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And other researchers are searching for ways to slow down or even turn back these biological clocks.
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Though so far, most attempts at this have been largely unsuccessful.
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Besides, researchers still don't know if telomeres,
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inflammation, or epigenetics are actually to blame for aging,
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or if they are simply neutral markers of other processes happening in the body.
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We may be learning to read the language of aging,
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but we still have a way to go in understanding its grammar.
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Do you ever feel like you don't know enough about your own body?
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Subscribe to this channel to learn about everything from baldness to muscle growth to why we have hair in such random places.
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Stay tuned and stay curious.
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المفردات والعبارات الرئيسية

  • Telomeres - التيلوميرات
  • DNA methylation - ميثيل الحمض النووي
  • biological age - العمر البيولوجي
  • chronic inflammation - الالتهاب المزمن
  • immune system - نظام المناعة
  • epigenetic clocks - ساعات الإبيجينيتيك
  • cellular senescence - شيخوخة الخلايا

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