シャドーイング練習: Narcolepsy Visually Explained - 動画で英語スピーキングを学ぶ

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Narcolepsy is a chronic sleep -wake disorder which classically causes the tetrad of excessive daytime sleepiness,
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cataplexy which describes sudden muscle weakness that can lead to collapse, dream -like hallucinations, and sleep paralysis.
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Disease onset is usually in a person's 20s, although it can be diagnosed at any age.
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Importantly, narcolepsy isn't actually that rare, being the second commonest cause of disabling daytime sleepiness after obstructive sleep apnea.
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Its estimated prevalence is about 1 in 1000.
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Most of the cases of narcolepsy are sporadic.
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However, there are familial clusterings suggesting either a genetic or environmental link.
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The disease can be classified into type 1 and type 2 narcolepsy.
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Type 1 is caused by extensive neuron loss in the hypothalamus.
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These specific neurons produce orexin, also referred to as hypocretin,
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which is a neuropeptide that stabilises the sleep and wake stages and prevents inappropriate transitions between them.
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As a result, this type is associated with very low levels of orexin and severe symptoms including cataplexy.
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Type 2 has normal orexin levels, including most of the same symptoms, but doesn't have cataplexy.
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The process that destroys the orexin -producing neurons remains a bit of a mystery,
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but more than 98 % of people with type 1 narcolepsy have the HLA -DQB1 gene.
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This suggests there might be an autoimmune element to it.
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Let's discuss the main clinical features.
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All patients with narcolepsy have excessive daytime sleepiness.
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This can be associated with memory problems and attention issues, resulting in incidents like car crashes.
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The Epworth Sleepiness Scale can be used for evaluating excessive daytime sleepiness.
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People with narcolepsy are also prone to sleep attacks.
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These occur in inappropriate situations several times a day, even when fully involved in a task, and last between one minute and one hour.
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In addition to sleepiness, narcolepsy also characterised by disordered regulation of rapid eye movement sleep.
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REM sleep normally occurs only during the usual sleep period, and includes vivid story -like dreams,
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rapid eye movements, and paralysis of nearly all skeletal muscles except the muscles of respiration.
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In narcolepsy, REM sleep can actually occur at any time of the day, intruding into wakefulness.
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The most severe manifestation of this is cataplexy, which occurs in 60 % of patients.
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This is a generalized muscle weakness, leading to partial or complete collapse.
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It is most frequently triggered by emotional stimuli such as laughter, excitement, or anger.
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Speech may be impaired, vision might be blurred, and respiration might become irregular during the attack.
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Many people with narcolepsy also complain of sleep paralysis, which occurs at the borders of sleep, typically when waking up.
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This is often associated with dreamlike and often disturbing hallucinations.
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Hallucinations that occur at the onset of sleep are referred to as hypnagogic hallucinations,
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and those that occur on awakening are referred to as hypnopompic hallucinations.
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Typical hallucinations might include the sense that a threatening stranger is in the bedroom, or that one's being attacked by animals.
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Moving to investigations, the clinical history of narcolepsy often makes the diagnosis apparent,
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but it's essential to confirm it with overnight polysonography, followed by multiple sleep latency tests the next day.
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The PSG ascertains sleep quality and can identify coexisting causes of excessive daytime sleepiness such as OSA.
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In people with narcolepsy, it might show fragmented light sleep and an early transition into REM sleep.
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The MSLT is performed the day after.
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In this test, the patient is encouraged throughout the day to fall asleep every 2 hours for 20 minutes.
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Given the opportunity to nap, nap, people with narcolepsy usually fall asleep in less than 8 minutes,
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whereas healthy people generally fall asleep in more than 15 minutes.
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In addition, people with narcolepsy will have REM sleep during at least two of these daytime naps.
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The management of narcolepsy is based on lifestyle modifications and medications to treat excessive daytime sleepiness and cataplexy.
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Non -pharmacological approaches should include improving sleep hygiene by adopting a relatively strict sleep schedule and avoiding alcohol,
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smoking, late late night exercise and sleep deprivation.
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Excessive daytime sleepiness can be managed with CNS stimulants.
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One first -line medication is modafinil.
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Other medications, including dexamphetamine and methylphenidate like Ritalin,
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have evidence, but a lack of head -to -head trials makes it difficult to compare efficacy between drugs.
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Cataplexy is usually managed with sodium oxabate or bitosaline.
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These reduce the frequency of attacks per week second -line agents such as serotonin noradrenaline reuptake inhibitors
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or tricyclic antidepressants can also be considered.
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To remember the classic triad of clinical symptoms for narcolepsy, remember CHESS features, including cataplexy,
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hallucinations, excessive somnolence, and sleep paralysis.
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If you like this mnemonic, then check out some of my other videos in this playlist.

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このレッスンの語彙とスピーキングのポイント

このC1レベルのスピーキングレッスンは、動画「Narcolepsy Visually Explained」を教材にしています。 繰り返し出てくる語は次のとおりです:sleep, narcolepsy, sleepiness, daytime, cataplexy。 この動画には、シャドーイング用の文が57文、単語が767語あります。 音声の長さは5:51です。 話す速さは1分あたり約131語で安定しており、シャドーイングしやすいペースです。 英語の頻出3,000語に含まれる単語は68%だけなので、語彙は難しめです。

この動画の重要語彙

動画の中で特に難しい単語15語を、発音と意味つきで紹介します。

単語発音意味
narcolepsy 名詞/ˈnɑː(ɹ)kəˌlɛpsi/ナルコレプシー, 居眠り病
sleepiness 名詞眠気
daytime 名詞/ˈdeɪtaɪm/昼間
cataplexy 名詞/ˈkætəˌplɛksi/脱力発作, 情動脱力発作
hallucination 名詞/həˌluːsɪˈneɪʃən/幻覚, 幻想
paralysis 名詞/pəˈɹæləsəs/まひ状態, 麻痺
neuron 名詞/ˈn(j)ʊɹɑn/神経細胞
symptom 名詞/ˈsɪm(p)təm/症状, 症候
respiration 名詞/ɹɛspɪˈɹeɪʃən/呼吸
inappropriate 形容詞/ˌɪnəˈpɹoʊpɹi.ət/そぐわない, 場違いな
antidepressant 名詞抗うつ薬, 抗うつ剤
ascertain 動詞/ˌæsəˈteɪn/確かめる
autoimmune 形容詞/ˌɔːtəʊɪˈmjuːn/自己免疫の
awaken 動詞/əˈweɪkən/起こす
classify 動詞/ˈklæs.əˌfaɪ/分類する

動画に出てくる句動詞

単語発音意味
check out 動詞試験する, 検査する
wake up 動詞/ˌweɪk ˈʌp/目覚める, 目を覚ます

注意したい発音

  • 「th」の音: methylphenidate /ˌmɛθ əlˈfɛn ɪˌdeɪt/, threaten /ˈθɹɛt.n̩/
  • 「sh」と「zh」の音: hallucination /həˌluːsɪˈneɪʃən/, respiration /ɹɛspɪˈɹeɪʃən/, deprivation /ˌdɛp.ɹɪˈveɪʃən/, manifestation /ˌmænɪfɛˈsteɪʃən/, modification /ˌmɑdɪfɪˈkeɪʃən/
  • 長い単語(アクセントの位置に注意): narcolepsy /ˈnɑː(ɹ)kəˌlɛpsi/, cataplexy /ˈkætəˌplɛksi/, hallucination /həˌluːsɪˈneɪʃən/, paralysis /pəˈɹæləsəs/, respiration /ɹɛspɪˈɹeɪʃən/

日本語話者が苦手な音:

  • /r/ と /l/ の区別 — /l/ は舌先を歯茎につけ、/r/ はどこにもつけない: narcolepsy /ˈnɑː(ɹ)kəˌlɛpsi/, paralysis /pəˈɹæləsəs/, dreamlike /ˈdɹimlaɪk/, generalize /ˈd͡ʒɛn.(ə.)ɹə.laɪz/, noradrenaline /nɔːɹəˈdɹɛnəlɪn/
  • /v/ — /b/ にならないように、上の歯を下唇に当てる: deprivation /ˌdɛp.ɹɪˈveɪʃən/, obstructive /əbˈstɹʌk.tɪv/, prevalence /ˈpɹɛvələns/, vivid /ˈvɪvɪd/, evaluate /ɪˈvaljʊeɪt/
  • /f/ — 「フ」ではなく、上の歯と下唇で出す: classify /ˈklæs.əˌfaɪ/, familial /fəˈmɪljəl/, manifestation /ˌmænɪfɛˈsteɪʃən/, methylphenidate /ˌmɛθ əlˈfɛn ɪˌdeɪt/, pharmacological /ˌfɑɹməkəˈlɒd͡ʒɪkəl/

この動画での練習方法

  1. まず声を出さずに動画を最後まで聞き、知らない単語をメモします。
  2. 通常の速度で一文ずつシャドーイングし、話し手のリズムに合うまで繰り返します。
  3. 自分の声を録音して元の音声と比べます。narcolepsy, sleepiness, daytimeなどの単語に特に注意しましょう。

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