Pratique du Shadowing: Peptides Are Insane - Apprendre l'anglais à l'oral avec la vidéo
Création de la leçon...
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Peptides are kind of insane, and right now, they're everywhere.
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You cannot open social media without seeing a new peptide that'll transform your body.
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There's millions of people that are taking peptides, and it's radically improved their health.
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What if I told you that there was a peptide that tells your brain to grow new neurons?
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If you are not on peptides, I want to know why you are not on peptide.
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I am now on five different peptides.
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You're telling me I'm going to be able to inject myself with a Zenpec to lose the fat, and then inject myself with something else to keep the muscle? it's wild usually big claims like
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that trigger my detector right away and they did in this case too
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but the thing is peptides actually do work at least some
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of them do for the first time ever people can simply take a peptide like ozempic
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and fat seems to melt off like a lot this is
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what weight loss typically looks like over a year of diet
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and exercise and this is what weight loss typically looks like over a year of diet
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and exercise plus a glp1 peptide people have been struggling with fat loss for decades.
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So this is a huge shift and naturally it raises the question if peptides can do that, what else can they do?
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So I went down the rabbit hole.
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I pulled together all the studies I could find on peptides, the good and the bad.
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In this video, I want us to take these peptides together, see what happens inside our bodies and figure out which ones are actually worth the hype.
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At this point, I'm sure you've probably heard about peptides, but you may not know what they actually do a lot of people think of them like mini steroids
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but chemically no they're nothing like testosterone they're also not stimulants like the caffeine in your coffee they're not vitamins
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or minerals or anything like that biochemically they're actually most similar to protein
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if you take a scoop of protein powder
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and zoom all the way in the individual protein molecules look
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like this long tangled chains of amino acids you get a peptide
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if you untangle those long chains and cut them down into shorter chains of amino acids.
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There are about 20 amino acids in total that can be linked in different combinations to make millions of different peptides.
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But we can simplify all that down to the three kinds of peptides that health and fitness people really care about.
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First, the fat loss peptides.
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This is where most of the mainstream hype is coming from.
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These are the GLP -1 peptides like Ozempic.
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Second, the injury healing peptides like BPC -157, also known as the Wolverine peptides,
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and third, the anti -aging peptides that claim to help you stay fitter, healthier, and younger looking.
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Right now, one in every eight U .S adults say that they use fat loss peptides,
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and tens of millions of people are taking fat loss peptides right now across the globe.
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Obviously, this has become a really lucrative business, which is why I want to say up front that I'm not sponsored by any peptide companies.
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I do have a degree in biochemistry, and I've published peer -reviewed studies on muscle growth, and I'll be fact -checking this video with researchers and medical doctors to make sure it's as unbiased as possible.
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Easily the most famous fat loss peptide is this one.
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It's called semaglutide.
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It's a big GLP -1 peptide sold under the brand names Ozempic and Wegovy.
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To take semaglutide, you usually inject it because if you swallow it, it gets destroyed by the acid in your stomach.
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There is an oral version, but it's still degraded in the stomach, so you need a higher dose and special technology to help it get absorbed.
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Surprisingly, the oral version seems to be getting pretty close to the injectable version.
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After you inject semaglutide into a layer of fat, the peptide moves into the surrounding blood vessels and travels to three places, your pancreas, your stomach, and your brain,
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where it activates GLP -1 receptors.
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That tells your pancreas to stabilize your blood sugar, your stomach to slow down its emptying, and your brain to stop sending so many hunger signals.
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Those three effects create one very simple, yet very powerful super effect.
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You feel less hungry.
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Unlike pretty much every other fat loss supplement, semaglutide works in a pretty unique way.
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It doesn't claim to burn more fat.
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It also doesn't claim to boost your metabolism.
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Instead, what it does is it simply lowers your appetite.
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So you just eat less calories without really noticing it.
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And that really works.
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Because back in 2018, right before the peptide hype started to take off, 2 ,000 people volunteered to take semaglutide for the first time.
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But here's the thing.
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The researchers only gave some of the subjects real semaglutide.
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They gave the other subjects a fake placebo that looked like semaglutide, but it didn't have any actual semaglutide in it.
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None of the subjects knew whether they were taking the real semaglutide or the fake placebo semaglutide, and all the subjects were told to exercise and given dietary counseling.
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Everyone's average weight was 232 pounds on day one.
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The group taking semaglutide lost 34 pounds in 16 months on average,
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but the group taking the fake placebo semaglutide only lost six pounds.
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That's 34 pounds of weight loss versus six pounds of weight loss, with the only difference being a single peptide.
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But that was 2018.
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These days there are newer peptides that honestly kind of wipe the floor with Ozempic.
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For example, compared to semaglutide's 15 % weight loss, a newer peptide called terzepatide caused 23 % weight loss in a similar time frame.
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And retitrutide just passed through phase 3 clinical trials caused 28 % weight loss.
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That means if you started at 250 pounds and took retitrutide for about a year and a half, you'd be expected to lose around 71 pounds.
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The reason they work so well is that semaglutide only activates one receptor, GLP -1, but terzepatide activates two receptors, GLP -1 and GIP.
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Reditrutide activates three, so your hunger gets even more blunted and there may be a metabolic effect too.
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The thing is, these fat loss peptides clearly do work, but are there long -term health issues?
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Are they even safe?
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right hey buddy what's up man you hear me yeah yeah can hear you loud and clear
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so you prescribe weight loss peptides to patients right yeah uh i've been fully board certified since 2014
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and on so i don't think there's really any doubt at this point
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that they work right yeah they are the most effective, non -surgical way for weight loss, yes.
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Would you say that there's any doubt about whether they're safe or not?
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No, there doesn't seem to be any big smoking gun.
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There are some potential very rare things
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that may not show up in a randomized controlled trial where
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you just don't have enough people to see some of these rare things.
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They're extremely safe, especially in the indicated population.
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In your clinical practice, have you run into any issues with patients
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or do most people seem to tolerate them pretty well by
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far the most common side effect you see in the trials
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and what we see clinically is nausea
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and vomiting at the severe level high in the beginning
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when you start the medicine but over time the nausea just goes down the other things
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that we see constipation things get slower in the gi tract
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and that actually doesn't go away over time the constipation stays constant
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but other weird side effects people feeling like they have uti
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i've had some patients with developing gallstones i haven't had any patients with gallbladder attacks
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but you see it once in a while
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but that's still relatively rare as well for what it's worth of the three weight loss peptides
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that i've focused on semaglutide and trisepatide have fda health canada
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and european medicines agencies approval retitrutide is just now getting through phase three clinical trial
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so it doesn't have approval yet but based on what i've seen also seems to be tolerated pretty well overall.
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Yeah, very similar.
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Maybe a slight increase risk of nausea, vomiting, and a few other things.
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But really, until you do head -to -head, you won't know for sure.
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But it looks pretty similar.
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These peptides do have a dark side, though.
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This January at the gym, a lot of people noticed that there wasn't the same New Year's rush as usual.
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I think that could be
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because a lot of people who set New Year's resolutions to
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lose weight this year simply just started taking a peptide instead of exercising, which sucks if true because exercise has mental health benefits
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that you simply can't replace and you will lose a lot of muscle if you take one of these peptides without lifting.
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In fact, without weightlifting and proper protein intake, about 40 % of the weight lost on the GLP -1 peptide is lean mass.
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That's almost certainly not due to the peptide itself, but simply the fact that people are just losing a lot of weight without eating enough protein or training hard enough.
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I do think a lot of people using GLP -1s do know about the risk of muscle loss though, because more people are using protein powder now than ever before
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which sounds great in theory
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but in some places it seems to be leading to protein shortages
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which may be causing the price of protein powder to skyrocket much more concerning is the fact
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that you technically need a prescription to get a glp1 peptide
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but a lot of people either won't qualify
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or don't want to get access through their doctor as a
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result swaths of people are buying them from black market
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and gray market sources online where there's often zero quality control
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that ease of access means that now they're being used by already lean, healthy people who are trying to get even thinner,
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which could further shift society's expectations about what a healthy or desirable body should look like.
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But to me, that's different than overweight people using them as medicine to try to help them get down to a healthier body weight.
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As someone who prescribes these medications to people, you'll often hear it's cheating, it's taking a shortcut.
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Do you see it as a shortcut?
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As someone who has to take a few medicines for my own diseases that I have, I have hypothyroidism, Hashimoto's, I would think of it similar to like put the fork down
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and start eating a DASH -like diet and do exercise for hypertension.
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Nobody shames anybody for taking an anti -hypertensive or tells them it's a shortcut.
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Obesity has biological drivers in it that we can't just necessarily out discipline or out willpower.
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And so it
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goes
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and hits the receptors in the brain to basically not have
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those same biological drivers anymore kind of evens the playing field
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so i don't see it like a shortcut at all yeah
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i think people almost like hate on shortcuts a little bit
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too much too right like to me there's a fine line between like taking a shortcut
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and just like working smarter if you can get the same outcome
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for like less torture on yourself why make it harder on
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yourself than it needs to be right there is a slippery
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slope there where you're just like always looking for the easy way out
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but like at the same time you know i don't think it's
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so black and white as to say like oh because it's a shortcut, therefore it's not a good thing.
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A good analogy would be like, okay, you got to go from New York to LA.
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Do you take the direct flight or do you drive?
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Do you take a train?
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Do you walk?
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Do you hitchhike?
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Do you bike there?
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We have newer technology.
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As long as it's safe and not harming people, why not utilize good new technology for the better?
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That's the way I would say it.
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Now, before we move on to the next category of peptides, should you take a GLP -1?
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Well, I think if you're already at a healthy body fat percentage, you feel good, and you're performing well, no. I do think diet and exercise should be your first go -to,
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but if you've been struggling to lose weight and you've talked to your doctor about this medication, I think that's a decision that you and your doctor can come to.
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We can debate whether the good outweighs the bad societally, but what isn't up for debate is that these peptides that we've covered so far clearly do a lot for fat loss.
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So then, what in the world do the other peptides do?
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Injuries suck, and they happen to every serious lifter at some point.
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And until recently, your main options for treating an injury were basically physiotherapy and maybe surgery if it was serious enough.
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But now, there's a peptide for that.
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It's called BPC -157, and it has absolutely raving reviews.
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You need to know about the BPC -157.
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BPC -157 is a miracle compound.
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It has anti -inflammatory properties, also blood -driving properties.
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It tells damaged tissues how to heal.
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BPC stands for Body Protection Compound.
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And it's surprisingly simple.
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Just 15 amino acids taken from a larger protective protein and human gastric juice.
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It was developed by Croatian researchers in the early 90s while studying potential healing effects it had in the stomach.
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To test those healing effects elsewhere, scientists gave BPC -157 to rats with an injured leg and discovered that,
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yeah, 50 % more blood vessels formed in the injured leg.
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More blood vessels should mean more blood flow and more nutrients going to the damaged tissue, which led later scientists to test BPC -157 in a variety of different tissues,
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including muscles, tendons, and ligaments.
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Once again, it accelerated healing everywhere it went.
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But there's a catch, and it's a big one.
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All those studies were done on rats, rabbits, and dogs, not humans.
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BPC -157, the wolverine peptide all over the internet, has only ever been formally studied in 30 people.
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That's it.
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Compared with semaglutide or terzepatide, which have been tested on tens of thousands of people across multi -year, phase 3, placebo -controlled clinical trials,
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BPC -157 has just three pilot studies with barely a small handful of subjects in each.
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To be fair, those pilot studies did show some promise for knee pain, bladder pain, and safety, but they're still plagued by really small sample sizes and no placebo or control group.
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There's no high -quality, well -controlled science.
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There are plenty of anecdotes, though, and I think they're worth something.
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I know people who've had an injury that's been nagging them for years suddenly heal up after taking BPC.
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The internet is full of similar stories.
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I was in a really bad car accident.
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I immediately started taking BPC that day.
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I was back at work in like two or three days.
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I've been running the BPC because I have some pretty bad elbow inflammation.
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But then a few days of being back on that, I have no issues, no inflammation, no pain.
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I healed a little knee injury.
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I healed some nerve damage.
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I've healed my gut.
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I've healed my shoulder.
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I know that it works, and I know that it works super fast.
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Eh, we need to be careful with these, though, because most injuries heal with time anyway.
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If you started taking BPC and your shoulder finally started feeling better after six weeks, it's tempting to credit the peptide, and maybe it was the peptide,
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or maybe your shoulder just started healing naturally on its own.
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Without a placebo -controlled trial, it's hard to know.
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In my opinion, the mechanism does make sense.
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The animal data is intriguing, and I hope more high -quality human research happens.
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But as of now, it's still not FDA -approved, it's banned by WADA, and sourcing it can be sketchy.
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So as frustrating as injuries are, I'd stick to the boring stuff for now.
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Manage your training loads, try to find pain -free variations, and gradually build yourself back up over time.
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If your injury isn't getting better, have it looked at by a qualified physical therapist.
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So before we cover the last peptide category, should you take BPC -157?
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I think, no. I just don't think that the human evidence is there.
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Sourcing can be sketchy, and even though the mechanism does make sense, I'd stick to the verified, safe, boring stuff for now.
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but injuries aren't what most people are truly worried about anyway it goes deeper than
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that but a lot of people are really worried about is aging getting older and looking older
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the most ambitious peptide
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that we've covered to date is this tiny little four amino acid peptide called epitalon
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because unlike the glp1 peptides that promise weight loss
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or the injury peptides that promise healing epitalon is aiming at something much bigger
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aging itself epitalon works by targeting the most fundamental structure in
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your entire body your dna every muscle tendon organ blood cell
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that you've ever had has come from instructions encoded in your dna
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and to keep those instructions protected your dna is packaged up
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into chromosomes with these little caps on the end called telomeres as we get older those telomeres get shorter
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and shorter and that may be one of the key reasons why we age in the first place
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And it's why so much anti -aging research is focused on telomeres.
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So this is where the peptide epitalon comes in.
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It activates an enzyme called telomerase, which helps rebuild those protective telomeres as they shorten over time.
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Sounds promising on paper, but does epitalon actually increase lifespan in the real world?
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Well, actually, yes.
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Yes, it does.
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At least it does in flies, mice, and rats.
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Unfortunately, when it comes to increasing our human lifespans, the only studies that we have is this 2003 study from Russia, and this 2006 study from the same Russian research group,
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and neither study was independently replicated outside of Russia.
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There's little doubt that telomeric shortening is involved in the aging process, but over -activating telomerase may be involved in cancer development, so it is a delicate balance.
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And when it comes to epitalon, and frankly the rest of these peptides, the human evidence on anti -aging specifically just really isn't there at all that's kind of okay though
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because humans are already uniquely well adapted for longevity
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when you compare humans to other mammals of a similar size you consistently see
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that humans live much longer and virtually all the compounds out there
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that are being marketed as anti -aging solutions follow a similar
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pattern they probably work in rats they might work in pigs sometimes they'll work in other primates
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and then they do basically nothing when it comes to humans
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but we don't really need to look for a peptide to help us live longer anyway
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because the science is already quite clear on what helps slow aging down in humans.
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It's relationships, friends, family, and community.
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That's the big one.
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And the rest is the same boring stuff you've heard about before.
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Exercise, sleep well, don't smoke, don't drink too much, and try to maintain a healthy body weight.
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Not as sexy as a new anti -aging peptide, but those truly are the things that move the needle the most.
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So should you take an anti -aging peptide i think no the human evidence is just really really scant
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and like i said we already know what helps with aging
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the most it's the boring stuff my key message with this video is
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that just because there are certain peptides
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that do work for weight loss doesn't mean that everything
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that falls under the category peptides will work for everything it's
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ultimately your daily habits that'll determine how well you follow through on your health and fitness goals
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one habit
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that i follow through on pretty much every day is tracking
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my nutrition with macro factor i'm a part owner of the app
251
and we've done everything possible to make it the easiest simplest
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and most intuitive nutrition app on the market it isn't just
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a tracker though it uses science -based algorithms to learn your specific metabolism
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and then updates your calories and macros over time to mathematically guarantee
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that you get to your goal as long as you stick
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to the plan we have a really amazing community with over 500 000 users
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and i think the app's reviews and testimonials speak for themselves
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if you'd like to try it out just use code jeff
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when you download on the app store or google play
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and that'll get you two weeks for free there are zero ads on the app
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and we'll never sell your data and we have 24 -hour support
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if you ever run into anything that you're not sure about
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so click the first link in the description box below
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or scan this qr code on screen if you've never tracked your nutrition before
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or you just haven't been consistent with it i really think
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macro factor will help you get to where you want to be that's it for this one guys thank you
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so much for watching and i'll see you all here in the next soon.
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Vocabulaire et conseils d’expression pour cette leçon
Cette vidéo contient 267 phrases et 3590 mots à répéter en shadowing. La partie parlée dure 19:05. Le locuteur parle vite, environ 188 mots par minute : attendez-vous à des liaisons et à des sons réduits. Seuls 81 % des mots font partie des 3 000 mots les plus courants en anglais, le vocabulaire est donc exigeant.
Vocabulaire clé de cette vidéo
15 mots de la vidéo à retenir, avec leur prononciation et leur sens :
| Mot | Prononciation | Sens |
|---|---|---|
| heal verbe | /ˈhiːl/ | guérir, assainir |
| acid nom | /ˈæsɪd/ | acide |
| muscle nom | /ˈmʌs.əl/ | muscle |
| stomach nom | /ˈstʌmək/ | estomac |
| rat nom | /ɹæt/ | rat, souris |
| bore verbe | /boɹ/ | ennuyer, barber |
| receptor nom | /ɹɪˈsɛp.tə/ | récepteur |
| tissue nom | /ˈtɪʃ.(j)u/ | tissu |
| vessel nom | /ˈvɛsəl/ | vaisseau |
| powder nom | /ˈpaʊ.dɚ/ | poudre |
| compound nom | /ˈkɑmpaʊnd/ | composé |
| nutrition nom | /njuːˈtɹɪʃ.ən/ | nutrition |
| hype nom | /haɪp/ | matraquage publicitaire, promotion |
| researcher nom | /ˈɹiˌsɝ.t͡ʃɚ/ | chercheur, chercheuse |
| nausea nom | /ˈnɔzi.ə/ | nausée |
Les verbes à particule que vous entendrez
| Mot | Prononciation | Sens |
|---|---|---|
| go down verbe | descendre | |
| figure out verbe | cerner | |
| get through verbe | /ɡɛt ˈθɹu/ | franchir |
| pass through verbe | traverser | |
| slow down verbe | ralentir, décélérer | |
| take off verbe | enlever, ôter |
La grammaire de cette vidéo
Les structures que le locuteur utilise le plus, avec les mots exacts de la vidéo :
| Structure | Dans la vidéo |
|---|---|
| Present perfect continu have/has been + -ing — une action commencée avant et toujours en cours | have been struggling · you've been struggling · I've been running |
| Present perfect have/has + participe passé — une action passée qui compte encore maintenant | you've probably heard · has become · I've published |
| Voix passive be + participe passé — l’accent est mis sur ce qui arrive, pas sur qui le fait | can be linked · were told · be expected |
| Propositions relatives who / which + proposition — une précision sur une personne ou une chose | business, which is · people who set · people who are |
Prononciation à surveiller
Le locuteur utilise 77 contractions et formes réduites, comme they're, don't, I've. Prononcez-les sous leur forme courte, telles que vous les entendez.
- Les sons « th »: algorithm /ˈælɡəɹɪðm̩/, therapist /ˈθɛɹəpɪst/
- Les sons « sh » et « zh »: tissue /ˈtɪʃ.(j)u/, nutrition /njuːˈtɹɪʃ.ən/, medication /mɛdɪˈkeɪʃən/, instruction /ɪnˈstɹʌkʃən/, inflammation /ɪnfləˈmeɪ̯ʃən/
- Mots longs — placez bien l’accent: naturally /ˈnæt͡ʃ.(ə.)ɹə.li/, biological /ˌbaɪ.əˈlɑ.d͡ʒɪ.kəl/, mechanism /ˈmɛk.ə.nɪ.zəm/, medication /mɛdɪˈkeɪʃən/, surprisingly /səˈpɹaɪzɪŋli/
Comment s’entraîner avec cette vidéo
- Écoutez la vidéo en entier une fois sans parler et notez les mots que vous ne connaissez pas.
- Commencez à la vitesse 0,75×, répétez phrase par phrase, puis revenez à la vitesse normale quand cela devient facile.
- Enregistrez-vous et comparez avec l’original, en faisant attention à des mots comme heal, acid, muscle.
Qu'est-ce que la technique du Shadowing ?
Le Shadowing est une technique d'apprentissage des langues fondée sur la science, développée à l'origine pour la formation des interprètes professionnels. Le principe est simple mais puissant : vous écoutez de l'anglais natif et le répétez immédiatement à voix haute — comme une ombre suivant le locuteur avec un décalage de 1 à 2 secondes. Les recherches montrent une amélioration significative de la précision de la prononciation, de l'intonation, du rythme, des liaisons, de la compréhension orale et de la fluidité.