Prática de Shadowing: Essentials: Diet & Nutrition for Mental Health | Dr. Chris Palmer - Aprenda a falar inglês com vídeo
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Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance.
Bem-vindo ao Huberman Lab Essentials, onde revisitamos episódios anteriores em busca das ferramentas mais potentes e práticas baseadas na ciência para a saúde mental, saúde física e desempenho.
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I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.
Eu sou Andrew Huberman, e sou professor de neurobiologia e oftalmologia na Stanford School of Medicine.
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And now for my discussion with Dr. Chris Palmer.
E agora para a minha discussão com o Dr. Chris Palmer.
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Chris, Dr. Palmer, thank you for being here.
Chris, Dr. Palmer, obrigado por estarem aqui.
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Thank you, Andrew, for having me.
Obrigado, Andrew, por me receber.
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I have a lot of questions for you, and I'm really excited about this topic
Eu tenho muitas perguntas para você, e estou realmente animado com este tópico.
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because I think most people know what mental illness is or they have some idea what that is.
porque eu acho que a maioria das pessoas sabe o que é doença mental ou tem alguma ideia do que isso é.
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Most people have some idea what nutrition is.
A maioria das pessoas tem alguma ideia do que é nutrição.
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Fewer people certainly know how closely those things can interact.
Menos pessoas certamente sabem o quão intimamente essas coisas podem interagir.
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I think everybody is familiar with the feeling of a food
Acho que todo mundo está familiarizado com a sensação de uma comida
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or the ingestion of a food making them feel good in the short term.
ou a ingestão de um alimento que os faz sentir bem a curto prazo.
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But I believe that very few people understand
Mas eu acredito que muito poucas pessoas entendem
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or are familiar with the fact that nutrition and our mental health interact in this very intimate, maybe even causal way.
ou estão familiarizados com o fato de que a nutrição e a nossa saúde mental interagem dessa forma muito íntima, talvez até causal.
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And that is something that occurs over long periods of time, meaning what I ate yesterday, the day before, maybe even 10 years ago could be impacting the way
E isso é algo que ocorre ao longo de longos períodos de tempo, o que significa que o que eu comi ontem, anteontem, talvez até há 10 anos, pode estar impactando a forma
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that my brain and body are making me feel now.
que meu cérebro e meu corpo estão me fazendo sentir agora.
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So if you would, I'd love for you to just tell us about a little bit of the history,
Então, se puder, eu adoraria que você nos contasse um pouco sobre a história.
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in particular, your history with exploring the relationship between nutrition and mental health.
em particular, sua trajetória explorando a relação entre nutrição e saúde mental.
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And then we can dive into some of the more particulars of ketogenic diets versus other diets
E então podemos nos aprofundar em alguns dos detalhes mais específicos das dietas cetogênicas em comparação com outras dietas.
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and some of the truly miraculous findings that you
e algumas das descobertas verdadeiramente milagrosas que você
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and others are coming up with based on real patients
e outros estão sendo desenvolvidos com base em pacientes reais
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and real experiences of people who suffer and then find relief by altering their nutrition.
e experiências reais de pessoas que sofrem e depois encontram alívio ao alterar sua nutrição.
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Sure.
Claro.
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This story really starts with my own personal story.
Essa história realmente começa com a minha própria história pessoal.
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I don't need to go into great detail, but to set the stage, when I was a kid, I definitely had mental illness.
Não preciso entrar em muitos detalhes, mas para contextualizar, quando eu era criança, eu definitivamente tinha uma doença mental.
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Started with OCD.
Começou com TOC.
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I went on to have subsequent depression, suicidality, all sorts of things.
Eu passei a ter depressão subsequente, ideação suicida, todo tipo de coisa.
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Somehow or another, I pulled myself together and got through medical school, actually did quite well in medical school, and then was doing my internship and residency at Harvard.
De uma forma ou de outra, eu me recompus e terminei a faculdade de medicina, na verdade me saí muito bem na faculdade de medicina, e depois estava fazendo meu internato e residência em Harvard.
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And at that point in time, I was diagnosed with metabolic syndrome.
E naquele momento, eu fui diagnosticado com síndrome metabólica.
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So I had high blood pressure, horrible lipids, and prediabetes.
Então, eu tinha pressão alta, lipídios horríveis e pré-diabetes.
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And I was doing everything right, supposedly.
E eu estava fazendo tudo certo, supostamente.
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I was on a low-fat diet and I was exercising regularly.
Eu estava em uma dieta com baixo teor de gordura e fazia exercícios regularmente.
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And year after year, my doctor kept telling me diet and exercise.
E ano após ano, meu médico continuava me dizendo para fazer dieta e exercício.
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I was doing everything he kept telling me to do.
Eu estava fazendo tudo o que ele continuava me dizendo para fazer.
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Everything was getting worse.
Tudo estava piorando.
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My blood pressure kept going higher.
Minha pressão arterial continuou subindo.
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And at some point, he said, you're going to have to go on medication for your prediabetes something for your cholesterol and something for your blood pressure.
E em algum momento, ele disse, você vai ter que tomar medicação para o seu pré-diabetes, algo para o seu colesterol e algo para a sua pressão arterial.
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So three pills, basically you're screwed.
Então, três pílulas, basicamente você está fudido.
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It's your genes.
É dos seus genes.
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You're just going to have to bite the bullet and take meds.
Você só vai ter que encarar a situação e tomar os remédios.
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As a physician, I knew what that meant.
Como médico, eu sabia o que isso significava.
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I knew that I'm in my 20s.
Eu sabia que estou na casa dos 20 anos.
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If I'm already on three meds for metabolic syndrome, I'm going to be screwed by the time I'm 40 or 50 and I'm probably going to be having heart attacks.
Se eu já estou tomando três remédios para síndrome metabólica, eu vou estar ferrado quando chegar aos 40 ou 50 anos e provavelmente vou ter infartos.
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I'd heard through the rumor mill that the Atkins diet could somehow help people improve their cholesterol and prediabetes.
Eu tinha ouvido boatos de que a dieta Atkins poderia, de alguma forma, ajudar as pessoas a melhorar seus níveis de colesterol e o pré-diabetes.
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I was highly skeptical.
Eu estava muito cético.
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And, you know, I believed everything I was taught in medical school.
E, você sabe, eu acreditava em tudo o que me ensinaram na faculdade de medicina.
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Why would my professors lie to me?
Por que meus professores mentiriam para mim?
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They knew what they were talking about.
Eles sabiam do que estavam falando.
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Low-fat diet was the thing to do.
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And the Atkins diet was clearly dangerous and reckless.
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And I had been trying the medical dogma for years, and it wasn't working for me.
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And so for whatever reason, I decided this is going to be my last attempt at something different.
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And then I'll just bite the bullet and go on meds.
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So I tried the Atkins diet.
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Within three months, my metabolic syndrome was completely gone.
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I probably lost about, you know, 10 pounds through this process.
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But everything got normal.
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And when I went back to my doctor, he was shocked.
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The thing that was the most striking to me after doing the diet for three months
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was not the fact that my metabolic syndrome was gone.
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That was my goal and it was a seemingly miraculous achievement because I got rid of everything with one dietary change.
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But the thing that I noticed was dramatic improvement in my mood, energy, concentration and sleep for the first time in my life,
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I started waking up before my alarm went off and feeling rested.
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That never happened to me before.
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I was meticulous about planning when my alarm went off
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and how many times I could push the snooze button in order to be on time for wherever I needed to be, whether it was school or the hospital or whatever.
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Prior to the diet, I always felt like there are two types of people in the world.
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There are these happy, peppy people who just are so positive and they've got energy and they have this saying, they like to work hard and play hard.
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But I never understood who the hell wants to play hard?
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Like who's got energy for that?
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Like, aren't you tired from working so hard?
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I assumed that they were just lucky and privileged.
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They either had good genetics or maybe they had good childhoods or good parents or something, something that I didn't have.
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What was the journey forward into the work that you're doing now?
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So within a few years, I'm, you know, an attending physician.
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I've got all these patients in my clinical practice with treatment-resistant mental illness.
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I'm in a tertiary care hospital.
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So I almost never get somebody off the street with their first episode of depression.
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Out of the gate as part of my career, I get treatment-resistant mental disorders.
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So I get people who've already been to six-plus psychiatrists, therapists.
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They've usually tried dozens of different medications.
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They've been in decades of psychotherapy.
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They've often had ECT and other things.
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And nothing's working.
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And I'm thinking, you know, well, we're kind of out of options for these other people.
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And this diet is having this really powerful antidepressant effect.
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I think I'm going to try it and just see
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if any of my patients are game to try it to see if it might help them.
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Sure enough, it did.
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It didn't help everyone and not everybody was interested and or able to do it.
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But some of the ones who were able to do it ended up having a remarkable and powerful antidepressant effect.
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One woman actually became hypomanic within a month.
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And she had been depressed pretty much non-stop for over five years.
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Chronically depressed, suicidal, in and out of hospitals.
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And I saw her become hypomanic and I'm thinking, wow, this really is a powerful antidepressant effect.
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Like this is amazing.
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This is like a medication, but better because it actually is working for her.
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At that point, we didn't have many clinical trials of the safety
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or efficacy of Atkins diet for even weight loss or diabetes, let alone any mental disorders.
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And so I really actually felt like I'm on the fringe here
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and this is not going to be met with praise by anyone.
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So I'm just going to lay low.
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I'm going to offer it to patients.
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And I went along that way up until 2016.
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So low carbohydrate diet, certainly low sugar.
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Yeah.
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I'm assuming you're not a nutritionist.
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So how did you prescribe a nutrition plan for your patients?
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The first few patients, it was try this Atkins diet, I want to see ketosis.
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So I was strongly recommending that patients achieve urinary ketosis.
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And the interesting thing is I noticed a pattern that when they were trying the diet and not getting ketones, they often did not get a clinical benefit.
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It was once they got into ketosis that I began to notice the clinical benefit.
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The thing that completely upended everything that I knew as a psychiatrist though was when I helped a patient in 2016.
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33-year-old man with schizoaffective disorder.
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He had been my patient for eight years now.
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He had daily auditory hallucinations.
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He had paranoid delusions.
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He could not go out in public without being terrified.
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This man was tormented by his illness.
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It ruined his life.
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He had already tried 17 different medications and none of them stopped his symptoms.
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He weighs 340 pounds and for whatever reason he gets it in his head, I'm never gonna to get a girlfriend if I don't lose some weight.
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He also recognizes I'm never going to get a girlfriend because I'm a loser, I'm schizophrenic, I live with my father, I have nothing going for me.
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For a variety of reasons we ended up deciding to try the ketogenic diet.
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He decides to give it a try.
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Within two weeks, not only does he start losing weight, but I begin to notice this dramatic antidepressant effect.
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He's making better eye contact.
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He's smiling more.
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He's talking a lot more.
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I'm thinking like what's gotten into you?
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Like you're coming to life.
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Like I've never heard you talk this much.
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I've never seen you so excited or present or alive.
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I haven't changed his meds at all.
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The thing that upended everything that I knew as a psychiatrist was six to eight weeks in, he spontaneously starts reporting.
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You know those voices that I hear all the time?
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they're going away.
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And he says, you know, you know how I always thought
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that there were all these families who were controlling my thoughts
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and out to get me and they had targeted me and I'm thinking, oh yeah, we've been talking about that for eight years.
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We could talk about that again.
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He says, now that I think about it, I don't think that's true.
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And now that I say it, it sounds kind of crazy.
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It probably never was.
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I've probably had schizophrenia all along like everybody's been trying to tell me and I think it's going away.
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He's now lost 160 pounds and kept it off to this day.
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He was able to do things he had not been able to do since the time of his diagnosis.
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He was able to complete a certificate program.
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He was able to go out in public and not be paranoid.
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He performed improv in front of a live audience.
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At one point, he was able to move out of his father's home and live independently.
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Did he stay on any kind of antipsychotic or other medication?
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We have slowly but surely tried to taper him off his meds.
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He has been on meds for decades.
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He started medications when he was a young child.
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His brain is developed in response to all sorts of psychiatric medications.
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And it has not been easy to try to get him off.
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And I just want to say for any listeners, getting off your meds is very difficult and dangerous
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and you need to do it with supervision with a mental health professional or a prescriber.
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To stay in ketosis, what sort of blood levels of ketones do you like to see in your patients?
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What is the range that you think most people could aspire to?
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So it really depends on the patient and what I'm treating, quite honestly.
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And I don't think every patient needs the ketogenic diet.
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For some patients, simply getting rid of junk food can make a huge difference in a mood disorder, for instance.
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So a junk food meaning highly processed food, food that could last on the shelf a very long time.
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Highly processed foods that are usually high in both sugar, carbs and fats.
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Those seem to be the worst foods.
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That combination, high sugar, high fat, seems to be the worst combination for metabolic health and lo and behold,
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we've got emerging data that strongly suggests it's also bad for mental health.
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So to step back from that.
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So for some patients, I might just want to decrease glucose
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and insulin levels and I can do that by getting rid of sweets.
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For other patients, like patients with schizoaffective disorder or schizophrenia or bipolar disorder, especially if it's chronic, if I'm using it as a brain treatment,
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then I do want a ketogenic diet and I usually want reasonably high levels of blood ketones.
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For depression, I want to see at least greater than probably 0.8 millimole.
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For psychotic disorders and bipolar disorder, I usually want to see levels greater than 1.5.
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That's what I'm shooting for, if at all possible.
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I think that for a lot of listeners
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and people out there who are familiar with how changing your diet
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or changing your exercise can positively impact sleep and weight and all these things.
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And it cascades into feeling better.
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That makes perfect sense.
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But for a lot of the world still,
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the idea that changing or using nutrition as a dissection tool or as a treatment tool
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to understand and treat mental illness is still a kind of heretical idea.
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That to them, it kind of falls in the, okay, well, that's like a woo science or something like that.
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they immediately think, didn't Atkins die of a heart attack?
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You know, I hear that a lot, you know, which I do think is throwing the baby out with the bathwater, but it's an interesting thing nonetheless.
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And then I think that the majority of people sit in the middle
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and just want to see science and medicine come up with treatments that work.
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And I have to say, I'm very relieved to hear what you said earlier, which was you never said that people should come off their medication and just become, go on a ketogenic diet and everything will be cured.
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You're certainly not saying that.
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No. and rather you're saying, if I understand correctly,
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that nutrition needs to be considered one of the major tools in the landscape of effective tools
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and that it can be very effective.
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Let's talk about epilepsy and how the ketogenic diet is not just used for epilepsy, but is one of the oldest,
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if not the oldest examples of the use of nutrition to treat a condition of the nervous system
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that can be incredibly debilitating, even deadly.
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The reality is that this literature and this clinical history
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and all of the research we have was the godsend that I needed to do the work that I'm doing.
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Otherwise, I would have been discredited on day one.
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The ketogenic diet, unbeknownst to most people, was actually developed 100 years ago,
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1921, by a physician for one and only one purpose, to treat epilepsy.
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It wasn't developed as a weight loss diet.
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It wasn't developed as the diet that all human beings should follow.
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And the reason it was developed is because of this long-standing observation since the time of Hippocrates that fasting can stop seizures.
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Most people think going without food is bad and they equate it with starvation.
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But in fact, when we go without food, it causes tremendous shifts in metabolism, both brain and body metabolism.
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And it puts the body into a mode of autophagy
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and conservation of resources and all sorts of things that are beneficial to human health.
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And this is why fasting has been used as a therapeutic intervention in almost every culture and almost every religion for millennia.
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But for the most part, that was all thought to be religious folklore.
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In 1921, one physician used intermittent fasting on a child with seizures and found that,
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oh, lo and behold, this religious folklore stuff has something to it.
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It actually worked.
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The problem with fasting is that you can only fast for so long before you starve to death, and that's not a very effective treatment.
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As soon as people start eating a normal diet again, their seizures usually come right back, oftentimes with a vengeance.
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And so it can be a good short-term intervention.
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The fasting can take a few days because it can take a few days to get ketosis.
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And then you can get some relief from chronic seizures.
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But it's not a good long-term treatment because, again, people will starve to death.
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As soon as they start eating, seizures come back.
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So it was actually Dr. Russell Wilder at the Mayo Clinic who developed the ketogenic diet with one and only one purpose.
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He wanted to see can we mimic the fasting state using this special diet
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to see if it might stop seizures long term.
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And lo and behold, it worked.
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Early results were extraordinarily positive.
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50% of patients who use the ketogenic diet became seizure free
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and another 35% had a 50% or greater reduction in their seizure frequency.
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So about 85% efficacy rate.
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By the 1950s, pharmaceuticals were coming out and we had many more anticonvulsant treatments.
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And there's no question they work for a lot of people.
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That's great.
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And taking a pill is so much easier than doing this diet.
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But lo and behold, even to this day, people with epilepsy, about 30% don't respond to the current treatments that we have available.
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30% will have treatment resistant epilepsy, which means they continue to have seizures no matter how many anticonvulsants they're taking, even if they've had brain surgery.
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It just doesn't stop their seizures.
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And so in the 1970s, the ketogenic diet was resurrected at Johns Hopkins for these treatment-resistant cases.
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And lo and behold, it works.
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Not for all of them, but it works.
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And about one-third becomes seizure-free.
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And these are people who've tried everything and nothing's working.
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So one third becomes seizure-free, another third get a clinical benefit, meaning a 50% or greater reduction in their seizure frequency,
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and the other third it doesn't seem to work.
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And so the reality that God send for me is
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that we have decades of neuroscience research on the ketogenic diet and what it is doing to the brain.
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We know that the ketogenic diet is influencing neurotransmitter levels, in particular glutamate, GABA, adenosine.
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It changes calcium channel regulation and calcium levels, which is really important in the function of cells.
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It changes gene expression.
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It reduces brain inflammation.
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It changes the gut microbiome and there are.. gut microbiome is a huge topic right now
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and there are some researchers who argue that is the primary benefit of the ketogenic diet.
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It's changing the gut microbiome in beneficial ways.
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So it's doing a lot of things.
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It obviously improves insulin resistance, It lowers glucose levels, lowers insulin levels, which improves insulin signaling.
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The key for my research that I've outlined,
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the real magic, is that this diet stimulates two processes that relate to mitochondria.
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It stimulates a process called mitophagy, which is getting rid of old and defective mitochondria and replacing them with new ones.
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And it also stimulates a process called mitochondrial biogenesis, which means that after people have done the ketogenic diet for a while,
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months or years, many of their cells in their bodies and brains will have more mitochondria and those mitochondria will be healthier.
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And I believe that is the reason the ketogenic diet is such a powerful treatment,
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not only for epilepsy, but also for people with chronic mental disorders.
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If you're looking for randomized controlled trials documenting efficacy in large numbers of patients with these disorders, we don't have them.
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They're underway now, but we don't have them yet.
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Maybe we could just talk about mitochondria for a moment and then talk about these two major effects.
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What are some of the other things that mitochondria are important for in neurons and maybe other cells of the brain?
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If you think of the cell as a computer, a lot of people think of mitochondria as the power cord to that computer
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because they're providing the power and they are in fact the power cord to that computer.
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But actually their real function is the motherboard of that computer.
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So mitochondria are directing and allocating resources throughout a cell.
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That is their primary function and then they happen to be powerhouses as well.
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To give some clear examples,
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mitochondria play a direct role in the production and release and regulation of some really key neurotransmitters,
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including serotonin, dopamine, glutamate, acetylcholine.
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Those are pretty powerful neurotransmitters.
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Yeah, I would call those, I would consider those the, I know you listed more than three, but the sort of primary colors of neurotransmission.
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Yes.
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You know, any one of those in excess or deficiency is going to have profound negative effects on a nervous system.
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Mitochondria are providing both some of the building blocks, if you will, for some of those molecules.
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They're part of the Krebs citric acid cycle.
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Some of the intermediate products actually go into making those neurotransmitters.
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Much more importantly, mitochondria provide the energy for the production of those neurotransmitters and fascinatingly,
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mitochondria are directly related to the release of neurotransmitters.
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ATP alone is not enough.
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There have been some research studies that have actually found
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that mitochondria move along the membrane of the synapse to release batches of vesicles of neurotransmitters
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and that if the mitochondria are removed from the synapse and researchers flood that cell with ATP,
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neurotransmitters usually are not getting released.
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Mitochondria are doing other things.
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We don't entirely even understand what all they're doing or how they're doing it.
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But they're doing other things than just providing the power.
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Mitochondria at least play a role in all of the aspects of the human stress response.
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So when humans are stressed, either physically or psychologically, there are several things that happen.
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Increased cortisol, increased adrenaline, noradrenaline, inflammation, and gene expression, in particular in the hippocampus,
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occur with the stress response.
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And one group of researchers actually genetically modified mitochondria in four different ways
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and found that all those four buckets of stress response were impacted in one way or another.
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implying that mitochondria are somehow playing a role in those.
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In terms of their role in cortisol, we know that mitochondria actually have the enzyme required for the synthesis of steroid hormones.
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So that includes cortisol, estrogen, testosterone, and progesterone, some names that maybe everybody's heard of.
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So that means that if mitochondria are in short supply or dysfunctional,
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the production of those hormones may become dysregulated.
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Mitochondria play a direct role in inflammation and they turn the inflammatory system both on,
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or they at least play a role in turning the inflammatory system both on and off.
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One paper in Cell actually identified mitochondria as the key regulator in turning certain inflammatory cells off.
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and that when you inhibit mitochondrial function, those cells don't turn off.
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Mitochondrial levels of reactive oxygen species are a key signaling process to turn the inflammatory process off.
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Another study found that macrophages, so macrophages are an important immune cell that play a role in healing.
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So if you cut yourself,
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your body will send inflammation that way and send immune cells that way to try to heal your skin.
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And macrophages play an important role in that healing.
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One group of researchers tried to figure out how do macrophages know to switch between the different phases of wound healing?
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Because the macrophages do different things in the different phases of wound healing.
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And the conclusion of all of their research was
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that it's mitochondria mitochondria are sending the essential signals
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that change the state of the macrophages to induce these different phases of wound healing.
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So I've just talked about neurotransmitters, hormones, epigenetic expression, inflammation.
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For anybody familiar with the mental health field, they know these are like some of the key variables
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that researchers have been struggling with for decades trying to figure out how do these fit together.
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We know that all of those buckets
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can be disrupted in people with mental disorders and our field has struggled to understand but how do they fit together?
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How can we make sense of this disruption?
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I believe once you understand the science of mitochondria,
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you can actually connect all of the dots of the mental illness What I'm hearing is that mitochondria,
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in addition to being important sources of energy production and output in cells, which of course they are,
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probably have other roles and that maybe someday what we call mitochondria will actually be two or three different little subcellular organelle.
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In the landscape of science education, oftentimes people think, okay, energy production, there'll be a picture or a cartoon of mitochondria, like flexing its muscles.
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People go, okay, energy, mitochondria, mighty mitochondria.
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And then they'll think, oh, you know, they're just sort of like a dumb jock portion of the cell, right?
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They're not doing anything sophisticated.
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And everything you listed off is that they are doing many sophisticated intricate things within cells.
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So now that everyone is well aware
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that mitochondria are doing a large number of very important things in a very regulated way,
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let's talk about mitophagy, which I have to presume is the intentional, or not, gobbling up of mitochondria,
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presumably to replace them with newer, healthier mitochondria.
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Is that right?
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It is.
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In many ways, mitophagy is a subset of autophagy, but it's got its own name because it is specific to mitochondria.
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There do appear to be some unique regulators of mitophagy compared to autophagy more broadly.
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Mitochondria actually are playing a role in autophagy itself.
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and this makes sense because the global picture of autophagy is stimulated by fasting states
341
or fasting mimicking states so when your body senses that you don't have enough food,
342
it actually hunkers down
343
and starts to recycle dead old parts in this kind of in a carefully orchestrated way and it takes them to lysosomes,
344
they get degraded and then those degradation products get used for either energy or to build new things.
345
Ontophagy is always occurring at a low level, but you can really hyper stimulate the process through fasting,
346
calorie restriction, fasting mimicking diets, other things.
347
And this is why fasting and calorie restriction is
348
so kind of such hot topics in the medical field now is
349
because they've been shown to induce longevity and we think it's probably through that process
350
that you're stimulating the body to become lean and conservative in terms of its allocation of resources.
351
And the body doesn't just destroy the healthiest tissue along with the old dead stuff.
352
It has these processes that identify the old and defective parts first
353
and they go first and that's what's beautiful about the whole thing and that's why fasting is so important.
354
So mitophagy we know plays a really important role
355
because there's this term called mitochondrial dysfunction
356
which some researchers are actually wanting to get rid of and move away from because as you just said, mitochondria do so many different things
357
and different mitochondria even within the same cell may very well be specializing in different tasks
358
And mitochondria from one cell to another are sometimes doing very different things.
359
Like not all mitochondria can produce cortisol.
360
That's specific to specific cells where those genes are getting turned on.
361
So it's not like all mitochondria are producing cortisol.
362
Just the ones in your adrenal gland, for instance, are producing cortisol.
363
And it has long been known for decades that mitochondrial dysfunction is associated with everything that ails us, essentially.
364
So David Sinclair published a paper in one of the cell journals, I think, saying that, oh,
365
mitochondria are actually the unifying link of everything that we know about aging.
366
Defective mitochondria or defective mitochondrial function,
367
mitochondrial dysfunction is possibly the unifying cause of aging and all of the aging related disorders.
368
So mitophagy is trying to address all that, is trying to say, okay, this is bad.
369
We don't want defective mitochondria.
370
And how can we get rid of old ones or defective ones and replace them with new ones?
371
And I think the most powerful signal and tool that we have right now is in fact related to diet.
372
It's calorie restriction.
373
That is the oldest, truest, best proven way to prevent aging in a wide variety of animal species.
374
Fasting and intermittent fasting.
375
And again, you can only do those things for so long.
376
And then fasting mimicking diets can also stimulate this process of mitophagy.
377
So what about the typical person who's an omnivore eating some rice, some pasta?
378
Do you think that those people might feel far better
379
or even a little bit better if they were in a lower glucose state?
380
I ask this because I think there are a lot of people out there who suffer from full-blown depression,
381
but there are also a lot of people who suffer from moodiness and feeling not so great, subclinical depression.
382
Yes, burnout is what I would call it.
383
Yeah, and just feeling like some days are great and then other days they feel lousy for reasons they don't understand.
384
I kind of break this field and I'm probably getting too nerdy right now, but I kind of break this field into cause.
385
What's the actual root cause and what are effective treatments?
386
And I really see them as two separate things.
387
calorie restriction, ketogenic diet, carbohydrate restriction are inducing metabolic changes in the brain and body.
388
And regardless of what the person was eating,
389
they are inducing metabolic changes that can be really beneficial to brain health.
390
So going to your broader question about adults modern day, if it's an average person who is not currently under psychiatric care,
391
not taking prescription medicines, but is saying, I'm burned out.
392
I'm exhausted.
393
I want some of that brain energy that Andrew Huberman's talking about.
394
He talks about feeling good.
395
I want some of that.
396
I'm probably actually going to recommend, let's see if we can just carb restrict for a while and see if that produces clinical benefit.
397
I have one, he's not even a patient, just somebody who read my book, had chronic anxiety, was trying meditation, was trying all sorts of things.
398
He was ready to go on prescription medicine.
399
He read an early copy of the book.
400
He took it upon himself without consulting with me to restrict carbohydrates alone.
401
He did not go ketogenic.
402
He is a vegetarian.
403
He restricted carbs.
404
Within three weeks said, I don't need prescription medicine.
405
I can't believe how much better I feel.
406
And all I did was cut out some of the high carb foods in my diet.
407
So I think for some people, it can be that simple.
408
For people with serious mental disorders, if they are chronically depressed, if they're on lots of prescription meds, if they're disabled by their symptoms,
409
and certainly if you're bipolar or have schizophrenia or something,
410
those are the people I really do want them to work with a medical professional because meds may need to be adjusted.
411
They really need a real shot at this diet.
412
It's not like weight loss.
413
Weight loss, everybody wins it.
414
And either you're successful or you aren't.
415
You look on the internet or you read a book and seeing whether it works or not.
416
If you're using it to treat a serious disorder, I think you need serious help.
417
On behalf of myself and the listeners and certainly just on behalf of everybody out there, because everyone does need to be concerned about mental health issues,
418
whether or not they have them and in their family themselves or otherwise because they impact everybody.
419
Just really want to thank you for doing the work that you're doing.
420
You've given us a lot of hints into the underlying mechanisms that suggest as to why it would work.
421
And you've given us examples as to how it has worked in patients that you've worked with.
422
So thank you for being brave and for taking this on
423
and doing it in such a structured way
424
and for communicating it here today and with the general public through your book
425
and your online presence we will certainly point people in the direction of those valuable resources.
426
Thanks so much.
427
I really appreciate it.
428
Thank you, Andrew, for being brave and having me on your show.
429
It's been a pleasure.
430
And for a great conversation.
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Mesmo canal
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Vocabulário e dicas de fala para esta lição
Este vídeo tem 430 frases e 5412 palavras para praticar shadowing. A fala dura 34:40. O falante fala em ritmo natural, cerca de 156 palavras por minuto, próximo de uma conversa do dia a dia. Apenas 81% das palavras estão entre as 3.000 mais comuns do inglês, por isso o vocabulário é exigente.
Vocabulário principal deste vídeo
15 palavras menos comuns do vídeo, com pronúncia e significado:
- disorder /dɪsˈɔɹdɚ/ (substantivo) — desordem. Absence of order; state of not being arranged in an orderly manner.
- seizure /ˈsi.ʒɚ/ (substantivo) — apreensão, apropriação. The act of taking possession, as by force or right of law.
- medication /mɛdɪˈkeɪʃən/ (substantivo) — medicamento, medicação. A medicine, or all the medicines regularly taken by a patient.
- nutrition /njuːˈtɹɪʃ.ən/ (substantivo) — nutrição. The organic process by which an organism assimilates food and uses it for growth and maintenance.
- metabolic /mɛtəˈbɒlɪk/ (adjetivo) — metabólico. Of or pertaining to metabolism.
- illness /ˈɪl.nəs/ (substantivo) — doença, enfermidade. An instance (episode) of a disease or poor health.
- heal /ˈhiːl/ (verbo) — curar, sanar. To make better from a disease, wound, etc.; to revive or cure.
- researcher /ˈɹiˌsɝ.t͡ʃɚ/ (substantivo) — pesquisador, pesquisadora. One who researches.
- defective /dɪˈfɛktɪv/ (adjetivo) — defeituoso. Having one or more defects.
- behold /bɪˈhəʊld/ (verbo) — ver, contemplar. To look at or see (someone or something), especially appreciatively; to descry, to look upon.
- restriction /ɹɪˈstɹɪkʃən/ (substantivo) — restrição. The act of restricting, or the state of being restricted.
- inflammation /ɪnfləˈmeɪ̯ʃən/ (substantivo) — inflamação. The state of being inflamed.
- gene /d͡ʒiːn/ (substantivo) — gene. A theoretical unit of heredity of living organisms which may take several values and (in principle) predetermines a precise trait of an organism's form…
- syndrome /ˈsɪndɹoʊm/ (substantivo) — síndrome (masc. in pt-pt), síndroma. A recognizable pattern of signs, symptoms and/or behaviours, especially of a disease or medical or psychological condition.
- chronic /ˈkɹɑ.nɪk/ (adjetivo) — crónico. Of a problem, that continues over an extended period of time.
Phrasal verbs que você vai ouvir
- go on /ˈɡoʊˌɒn/ (verbo) — continuar. To continue in extent.
- come up with (verbo) — pensar (em), alcançar. To manage to produce, deliver, or present (something) by inventing, creating, thinking of, or obtaining it.
- end up (verbo) — terminar, acabar. To bring to a conclusion.
- figure out (verbo) — descobrir, deduzir. To come to understand; to discover or find a solution; to deduce.
- get into (verbo) — entrar em. To move into (an object), such that one ends up inside it.
- go away (verbo) — sair, partir. To depart or leave a place.
- go off (verbo) — explodir. To explode.
- burn out (verbo) — apagar-se. To destroy by fire.
Pronúncia para ficar de olho
O falante usa 112 contrações e formas reduzidas, como I'm, you're, don't. Diga-as na forma curta, do jeito que você ouve.
- Os sons de “sh” e “zh”: seizure /ˈsi.ʒɚ/, medication /mɛdɪˈkeɪʃən/, nutrition /njuːˈtɹɪʃ.ən/, restriction /ɹɪˈstɹɪkʃən/, inflammation /ɪnfləˈmeɪ̯ʃən/
- Palavras longas — acerte a sílaba tônica: medication /mɛdɪˈkeɪʃən/, metabolic /mɛtəˈbɒlɪk/, inflammation /ɪnfləˈmeɪ̯ʃən/, inflammatory /ɪnˈflæmət(ə)ɹi/, beneficial /ˌbɛn.ɪˈfɪʃ.əl/
Como praticar com este vídeo
- Ouça o vídeo inteiro uma vez sem falar e anote as palavras que você não conhece.
- Comece na velocidade 0,75×, faça shadowing frase por frase e volte à velocidade normal quando ficar fácil.
- Grave a sua voz e compare com o original, prestando atenção a palavras como disorder, seizure, medication.
Gramática neste vídeo
As estruturas que o falante mais usa, com as palavras exatas do vídeo:
| Estrutura | No vídeo |
|---|---|
| Present perfect continuous have/has been + -ing — uma ação que começou antes e continua | we've been talking · everybody's been trying · have been struggling |
| Present perfect have/has + particípio passado — uma ação passada que ainda importa agora | who've already been · They've usually tried · They've been |
| Voz passiva be + particípio passado — o foco está no que acontece, não em quem faz | was diagnosed · be screwed · was taught |
| Orações relativas who / which + oração — informação extra sobre uma pessoa ou coisa | people who suffer · people who just · ones who were |
O que é a Técnica de Shadowing?
Shadowing é uma técnica de aprendizado de idiomas com base científica, originalmente desenvolvida para o treinamento de intérpretes profissionais. O método é simples, mas poderoso: você ouve áudio em inglês nativo e repete imediatamente em voz alta — como uma sombra seguindo o falante com 1-2 segundos de atraso. Pesquisas mostram melhora significativa na precisão da pronúncia, entonação, ritmo, sons conectados, compreensão auditiva e fluência na fala.