跟讀練習: The Latest Developments in Age Reversal Research - 通過影片學習英語口語

選擇練習模式

每種模式都會開啟全屏練習室。

210 句

如果句子過短或過長，請點選 Edit 進行調整。

The Joe Rogan Experience What what is the current state of science?

As applied to longevity treatments like because I know that there's some pretty groundbreaking stuff that's in the pipeline right now Yeah,

it's so since 2019 a lot of what we talked about has come true,

which is the amazing thing We were speculating 2019 that we could potentially reverse aging

And that was a sin to say that as a scientist publicly in those days.

I put it in the book.

And it's actually come true since then, certainly for the lab, for mice, monkeys.

And now we have a human clinical trial, the first potential human age reversal technologies in people right now.

Listen, it completely seems logical.

The idea that that at one point in time would have been heresy in science to discuss it.

That seems crazy.

Like if we if people get old we understand the mechanism why couldn't we reverse it?

Well, I think for a long time we had to accept it in the way

that cancer used to be accepted 200 years ago probably there was nothing you could do about it

And then my colleagues and I found

that aging has a root cause That's the same in pretty much every cell in the body

and that we could control that and that there were genes that not only slowed it down

But in 2020 we had a big publication that showed we could actually safely for the first time reverse that process

like reinstalling software in the cell to make it work again.

And so what is the pro- is that using CRISPR?

Like what are you using to...

Well, we deliver genes into the body like CRISPR.

I have a little prop here I brought.

What is that?

In my pocket here.

This is a representation of how we deliver the age reversal genes.

It's a virus-like capsule that we make in the lab.

And this is what's going into the patients right now, into their eyes.

Whoa initially And the eye is a good place to start.

How do you pick the people to get on these tests?

They volunteer

I was really fortunate to see the first patient get dosed earlier this year

and That person bravely volunteered to be the first person to get

Trillions of these injected into his eye to see if it could cure his glaucoma loss of vision

I bet if you have glaucoma, you're probably like, listen, what's the worst that could happen?

Well, exactly.

He pretty much was totally blind in one eye, and so there's really nothing that he has to lose.

There's a risk that something might go wrong, but not really.

The good news is, and I can report to everybody around the world, that nothing's gone wrong so far.

Everything's proceeding according to plan, and we're at a turning point, potentially, in human history, if it works.

So I interrupted you but explain this little virus transport system.

Oh sure and for those of you listening I've got a little rubber ball with spikes on it.

It looks a bit like COVID but don't be scared of it.

It's not a pathogenic virus it's actually a domesticated version of a virus and this little plastic ball has little adapters.

These red balls on the surface of the big ball

target it to the cells in the back of the eye and you can change the balls to target different tissues.

We could change that outside little spike and target it to the liver, which we've done, and cured mice of their fatty liver disease as well.

But this one's for the eye, and within that big ball is a protein capsule,

and inside the protein capsule is our DNA special delivery, which we call OSK or Or ER 100,

ER 100 is Epigenetic Reprogramming 100, the drug that we know when we put it into human cells, it makes them younger.

And then they work like they were young again.

This sounds like the beginning of a horror movie.

You know what I mean?

Like the scientist is on a talk show, and the scientist is explaining it, and everyone's at home with their coffee like, wow, this is wonderful.

We're going to get younger again.

And then the scientist says, don't worry, it's all gonna work out great.

28 days later, garbage in the streets, cars on fire, the guy's waking up from a coma, doesn't know what happened, Yeah.

Goes outside, these optimized humans are eating each other.

I admit, I admit, it is science fiction, and I even have to pinch myself that it's actually happening.

But we've done a lot of safety studies, and this trial is FDA approved, because they've looked at all the data.

Well, God knows they never fuck anything up.

Yeah, I figured you might say that.

Perfect!

Yeah, well it's in the eye, so that's why we start with the eye.

It's enclosed.

It's not going to spread nobody's going to grow another eye.

And so these trillions of cells that you're putting into the eyes.

The little capsule the virus like particles.

I shouldn't call them cells.

Trillions of capsules that you're putting into the eye.

What are they doing for glaucoma?

Well, what they're doing is there are three genes in this DNA package and I call them OSK.

OSK are three special genes that we found safely reprogram cells

and reboot the backup copy of youth which we now believe exists in our body.

That's a big deal

that there's a backup copy of youth even an old person I don't see

that an old person anymore on the street I just see a person that needs to be rebooted.

These OSK genes...

You just see, wait a minute, hold on.

When you see old people, you don't see old people, you just say, oh, that poor person needs to be rebooted.

You're doing the perfect job for you.

Like, your personality is perfectly suited for your occupation.

If that's how you actually look at people?

Well, I do, and the reason is that we all have this backup copy that the DNA,

The instructions to be young that made us into who we are as kids is still in our bodies, almost largely intact.

You just need to read it again.

And that's why reinstalling software or...

I used to use the analogy of a CD.

Kids these days probably don't know what a CD is.

It's a little plastic circle like a record that we used to put 20 songs on.

It was awesome at the time.

I think most people know.

I'm kidding.

It's a bit of a silly joke.

Maybe a 10-year-old does.

When I teach kids at Harvard, most of them have never held a CD.

Isn't that wild?

Yeah.

Though they're not coming back, but albums definitely.

100

So think of it like an album that you scratch.

101

And the scratches are like aging, and we are getting rid of the scratches with these three genes, OSK.

102

So let me tell you how these three genes work, we found.

103

There was a person whose name is well known in science circles called Shinya Yamanaka,

104

from Japan obviously, and he discovered that there was a set of four genes that could reliably make adult cells,

105

like skin cells, into stem cells.

106

And he deservedly won the Nobel Prize for that in 2006.

107

But that wouldn't be useful here.

108

If I turned you into a bunch of stem cells, you'd probably die within a few minutes.

109

So we don't want to do that.

110

And cancer is also a potential.

111

So it took us about, well, from 2019 it took us a while to figure out

112

that if we leave out one of the Aminaka genes and just use three, OSK, leave out the other one called them, we get safe age reversal,

113

about 75-80% back to youth, but no further.

114

We don't go back to zero, which is what Yamanaka did.

115

And instead of cells losing their identity, which is what a stem cell has, no identity, we regain identity.

116

So it's actually, I could draw graphs, but it doesn't really help listeners.

117

But basically old age is losing identity of your cells, so they don't work, they forget how to work.

118

That's what we think old age in my lab and stem cells have no identity.

119

It was like a very early embryo.

120

In between, our cells have a lot of identity.

121

They function beautifully.

122

We're in our 20s.

123

We're at peak and what we've done is we've figured out how to go back towards youth, get these cells to work like they did again,

124

get the backup copy somewhere it exists.

125

We're looking for it and now cells actually behave like they did

126

when we were 20 and

127

if it works we're gonna have glaucoma patients seeing for the first time

128

and that's the beginning of a whole cascade of drugs that I want to develop

129

For diseases of aging and eventually whole body rejuvenation

130

So the initial experiments are on glaucoma

131

because it's a contained thing the eyeball is a contained thing And you could do it that way.

132

Yeah, my student one Cheng Lu who was doing this in

133

2017 I said let's do the liver Let's rejuvenate the liver

134

and he said no the eye is a good idea and he was right So that's exactly why we chose that first.

135

But just think about how many people have vision problems.

136

It's 40 million Just in the US for glaucoma

137

Macular degeneration is even more and in the lab we can cure

138

that as well in the mice now macular degeneration and

139

Glaucoma these are diseases of aging right you would say or glaucoma is a disease Oh, yeah What about people that have had eyeball injuries

140

and things like is there a backup copy of the eyeball where you could sort of reformat the eyeball structure?

141

You should come work in my lab at least come visit.

142

I would love to visit.

143

And the reason I say that is that's the exact question that we're asking.

144

Mmm.

145

We showed that even if you injure say a nerve

146

whether it's peripheral on in your arm or in your brain or in the eye like the optic nerve

147

we can regrow those back to where they were.

148

And actually in 2020, on the cover of Nature magazine, there was the picture of an eye.

149

And in the paper we published, you could see the nerves regrowing back.

150

And so we think that injury is also treatable.

151

Actually, a group in China just took out technology, this OSK stuff, put it into mice that had bad joints, and it regrew their muscle and their bone back to normal.

152

Whoa.

153

And so we're also looking at treating injury, back injury joints, osteoarthritis.

154

That would be phenomenal, because there's so many people that are suffering from arthritis.

155

I know so many people with injuries, like martial arts injuries.

156

I have one my left knee is fucked up.

157

It's annoying.

158

I keep it together I've got it like main I maintain it, but it's always an issue I have to stay on it.

159

I and there's little you can do like stem cells a little bit of relief

160

But not stem cells give you relief

161

But not when once you're dealing with cartilage damage

162

And you're dealing with the I had a meniscus surgery where they took out a piece of my meniscus

163

and I had my ACL Reconstructed on that knee as well.

164

It's it's just an issue

165

But it works pretty good for like what it should be like if we were living in the 1930s.

166

I'd be a cripple

167

You know hang in there

168

because we're gonna be in a world where you can rebuild parts of the body including joints The problem with

169

that is like how does that apply to athletics?

170

We're gonna have fucking super soldiers in every sport There's gonna be people in every sport

171

that could do what Michael Jordan didn't like leap from halfway across the basketball court and dunk

172

That's probably coming and there may be DNA tests to see if you've got these OSK genes inserted.

173

And we're working on it, working on a drink and a pill as well.

174

A drink and a pill?

175

Yeah, I mean we're now eight years ahead of what the public realizes.

176

Really?

177

In my lab at Harvard, yeah.

178

A drink and a pill, and what's a drink and a pill gonna do?

179

Well, right now it's in mice, so we've still got a ways to go, but when we give the drink to mice, they get rejuvenated.

180

You just give it to 80 year olds.

181

If you're on the way out, like, let's fucking go.

182

Like, give it a chance.

183

Well, this is what the FDA is for.

184

They forbid that.

185

Yeah, that's why we need to get rid of them.

186

Get rid of the FDA and just give it to old people.

187

If I was an old guy, and I was like, hanging in there, and I'm walking around with a...

188

And you're like, look, this drink and a pill might kill you, or you might be like a 30-year-old again.

189

I'm like, let's fucking go!

190

Let's fucking go!

191

Well, I get emails a lot.

192

I've had to take my emails off public access, Because there's a lot of people that want this.

193

Oh, I'm sure there was one guy

194

that wouldn't leave The building until he saw me so it's getting to that point Yeah, there's a little bit of that right people get a little selfish like it's all about them.

195

Yeah, and actually the US

196

Government blocked an investment from a foreign country into one of my companies because they were afraid of super soldiers

197

What country well they're afraid of technology getting out Which which country could I guess?

198

Sure.

199

China!

200

It wasn't. Was it?

201

No. Russia?

202

It was somewhere in between here and China.

203

Oh, well that's pretty vague.

204

It's a little, uh, it's a little sensitive.

205

But yeah, the US government does have the ability to block foreign investment and they did in this case.

206

160 million bucks they blocked.

207

Wow.

208

That was a painful episode.

209

So they were worried that people were gonna actually engineer super soldiers.

210

Thank you.

下載應用

流利口語所需的一切

AI 發音評分逐句打分

音標練習掌握每個音

詞彙學習建立你的詞庫

詞彙遊戲邊玩邊學

掃碼

Download on theApp Store Get it onGoogle Play

同頻道

Matt Damon on Saving Private Ryan and Steven Spielberg Being a Masterful Filmmaker

Daily ConversationUniversity StudentsWorking Adults

Joe Rogan Rants about Happiness

Business EnglishDaily ConversationUniversity Students

Time and Effort Will Make You a Better Person | Joe Rogan and CT Fletcher

Business EnglishDaily ConversationUniversity Students

Dan McClellan on the Origins of Adam & Eve and the Removal of Passages from the New Testament

Daily ConversationUniversity StudentsWorking Adults

Egyptian Pharaoh's Used Mummification to Download Consciousness

Daily ConversationWorking Adults

Will Conor McGregor Come Back and Fight Paddy Pimblett?

Daily ConversationUniversity StudentsWorking Adults

McGregor vs. Holloway 2: What to Expect at UFC 329

Daily ConversationUniversity StudentsWorking Adults

FOR YOU

本課的詞彙與口語要點

這節 B2 級別的口語課以影片“The Latest Developments in Age Reversal Research”為素材。影片中反覆出現的詞有：cell, eye, genes。這段影片共有 210 個句子、2411 個單詞可供跟讀。講話部分時長為 13:21。說話人語速較快，每分鐘約 181 個詞，會出現較多連讀和弱讀。 83% 的單詞屬於英語最常用的 3,000 詞，其餘的詞建議在練習前先學一下。

影片中的重點詞彙

影片中最難的 15 個單詞，附發音和釋義：

單詞	發音	釋義
glaucoma 名詞	/ɡlɔːˈkoʊmə/	青光眼
capsule 名詞	/ˈkæps(ə)l/	蒴果
pill 名詞	/pɪl/	藥丸 /藥丸, 藥片 /藥片
eyeball 名詞	/ˈaɪ.bɔl/	眼球, 睛球
reboot 動詞	/ˈɹiːbuːt/	重新啟動 /重新啟動
reversal 名詞	/ɹɪˈvɜː(ɹ)səl/	倒轉 /倒轉
scratch 動詞	/skɹæt͡ʃ/	抓, 劃
nerve 名詞	/nɝv/	神經 /神經
degeneration 名詞	/dɪˌdʒɛnəˈɹeɪʃən/	惡化 /惡化, 退行
meniscus 名詞	/məˈnɪs.kəs/	彎月面 /彎月面
reinstall 動詞		重灌, 重灌 /重灌
rejuvenate 動詞	/ɹɪˈd͡ʒuːvəneɪt/	返老還童 /返老還童, 恢復活力 /恢復活力
whoa	/woʊ/	籲
cartilage 名詞	/ˈkɑɹ.təl.ɪd͡ʒ/	軟骨 /軟骨
cascade 名詞	/kæsˈkeɪd/	瀑布

影片中出現的短語動詞

單詞	發音	釋義
figure out 動詞		弄清楚
take out 動詞		取出
come back 動詞		回來 /回來, 返回
go back 動詞		回去, 返回
work out 動詞	/ˌwɝk ˈaʊt/	計算 /計算, 算出

值得反覆跟讀的句子

影片中簡短而完整的句子，可以直接用在日常對話裡：

How do you pick the people to get on these tests?
You know what I mean?
We're going to get younger again.
I shouldn't call them cells.
If that's how you actually look at people?

影片中的語法

說話人最常用的結構，並附上影片中的原話：

結構	影片中的用法
“used to” used to + 動詞 — 過去的習慣或狀態，現在已不再如此	used to be · used to use · used to put
現在完成時 have/has + 過去分詞 — 過去發生但與現在仍有關聯的事	has come · we've done · have never held
被動語態 be + 過去分詞 — 強調發生了什麼，而不是誰做的	be accepted · be rebooted · is fucked
定語從句 who / which + 從句 — 補充說明人或事物	zero, which is · identity, which is

需要注意的發音

說話人用了 63 次縮略和弱讀形式，例如 we're, don't, you're。請按聽到的簡短形式來說。

“th” 音: pathogenic /pæθəˈd͡ʒɛnɪk/, arthritis /ɑːˈθɹ(a)ɪtɪs/, athletic /æθˈlɛt.ɪk/
“sh” 和 “zh” 音: degeneration /dɪˌdʒɛnəˈɹeɪʃən/, martial /ˈmɑɹʃəl/, selfish /ˈsɛlf.ɪʃ/, instruction /ɪnˈstɹʌkʃən/, occupation /ˌɑkjʊˈpeɪʃən/
長單詞——注意重音位置: degeneration /dɪˌdʒɛnəˈɹeɪʃən/, rejuvenate /ɹɪˈd͡ʒuːvəneɪt/, deservedly /dɪˈzɜːvɪdli/, domesticate /dəˈmɛ.stɪ.keɪt/, pathogenic /pæθəˈd͡ʒɛnɪk/

中文母語者容易讀錯的音：

/v/ — 不要讀成 /w/，上齒輕觸下唇: reversal /ɹɪˈvɜː(ɹ)səl/, nerve /nɝv/, rejuvenate /ɹɪˈd͡ʒuːvəneɪt/, bravely /ˈbɹeɪvli/, deservedly /dɪˈzɜːvɪdli/
詞尾子音 — 要讀清楚，後面不要加母音: reboot /ˈɹiːbuːt/, scratch /skɹæt͡ʃ/, nerve /nɝv/, meniscus /məˈnɪs.kəs/, rejuvenate /ɹɪˈd͡ʒuːvəneɪt/
/r/ 和 /l/ 的區別: reversal /ɹɪˈvɜː(ɹ)səl/, bravely /ˈbɹeɪvli/, cartilage /ˈkɑɹ.təl.ɪd͡ʒ/, peripheral /pəˈɹɪf(ə)ɹ(ə)l/, rebuild /ɹiːˈbɪld/

如何用這段影片練習

先完整聽一遍影片，不要開口，記下不認識的單詞。
先用 0.75 倍速逐句跟讀，熟練之後再回到正常速度。
錄下自己的聲音並與原聲對比，特別注意 glaucoma, capsule, pill 這類單詞。

什麼是跟讀法？

跟讀法 (Shadowing) 是一種有科學依據的語言學習技巧，最初開發用於專業口譯員的培訓，並由多語言者Alexander Arguelles博士普及。這個方法簡單而強大：您在聽英語母語原聲的同時立即大聲重複——就像是一個延遲1-2秒緊跟說話者的影子。與被動聽力或語法練習不同，跟讀法強迫您的大腦和口腔肌肉同時處理並模模擬實的講話模式。研究表明它能顯著提高發音準確性，語調，節奏，連讀，聽力理解和口語流利度——使其成為雅思口語備考和真實英語交流最有效的方法之一。

影子跟讀法: 閱讀完整分步指南 →

跟讀練習: The Latest Developments in Age Reversal Research - 通過影片學習英語口語

選擇練習模式

下載應用

Joe Rogan on Striking Specialists in MMA

John Cena on Being Initially Hated for His Persona and Turning Heel

Sean Sharaf on His Upset KO Against Gable Steveson

Reacting to Tesla's Flying Roadster

Max Holloway on Being Counted Out Before UFC 300 Win Against Justin Gaethje

Tony Hinchcliffe Reacts to Backlash Against His Kevin Hart Roast Jokes

Joe Rogan on Avoiding the Loser Mentality

Joe & Matt Walsh Go Back and Forth on the Moon Landing Conspiracy

Justin Gaethje on Beating Ilia Topuria to Become Champ at the White House UFC

Quentin Tarantino on Why He Thinks Movies Are Better Than TV Shows

Matt Damon on Saving Private Ryan and Steven Spielberg Being a Masterful Filmmaker

Joe Rogan Rants about Happiness

Time and Effort Will Make You a Better Person | Joe Rogan and CT Fletcher

Dan McClellan on the Origins of Adam & Eve and the Removal of Passages from the New Testament

Egyptian Pharaoh's Used Mummification to Download Consciousness

Will Conor McGregor Come Back and Fight Paddy Pimblett?

McGregor vs. Holloway 2: What to Expect at UFC 329

Contemporary Topics 3 Unit 11 BIOLOGY The fountain of youth

Would You Use An Artificial Womb? (I Would)

Latest advances in AVM treatment - Uday LIMAYE

Genetic Engineering Will Change Everything Forever – CRISPR

WHAT DO PEPTIDES ACTUALLY DO?

Personalised Cancer Care - Prof Mark Middleton

The CIA's new tech doesn't make sense

What Happens When Science Clashes with the Public?: Crash Course Scientific Thinking #7

Why This Is the Most Exciting Time to Be Human | Ken Ono, Axiom Math

Did Ancient Humans Really Live Longer Than Modern Humans?

How You Can Live Forever... Maybe.

Training W/ Real Life Vampire (Anti-aging)

本課的詞彙與口語要點

影片中的重點詞彙

影片中出現的短語動詞

值得反覆跟讀的句子

影片中的語法

需要注意的發音

如何用這段影片練習

什麼是跟讀法？