쉐도잉 연습: Appetite: Ghrelin and Leptin Explained - 영상으로 영어 말하기 배우기

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hey guys

so today's video is going to be on appetite control i'm going to be talking about the two main hormones

that regulate appetite so that includes ghrelin and leptin

and these guys are here to make sure

that you either don't get too fat or too skinny

so you don't have too many calories or too few by controlling hunger behavior

so because they're homeostatic hormones they obviously are going to act on the hypothalamus

so they each act on a different region of the hypothalamus

and either trigger hunger as in the case for ghrelin or satiety as in the case for leptin.

So let's get into a couple of details about ghrelin here.

So ghrelin is our appetite hormone.

An easy way to remember this is that when you're hungry your stomach growls.

So GHR for growl and that is for appetite.

All right

so this ghrelin hormone is produced by X cells in the stomach they release it into the bloodstream

and it travels to the lateral hypothalamus in the brain

this then causes the hunger response so it causes you to go seek and look for more food

all right another function of ghrelin is

that it's going to prepare the body for this food

so this ghrelin is going to go ahead

and act on the stomach itself and it's going to increase gastric motility

and gastric acid production to prepare the body for the food

that the lateral hypothalamus just ordered ghrelin is induced by two major inducers

so hypoglycemia and low body weight

so let's say you have low blood sugar as in the case for hypoglycemia or low

or you're very thin as in the case of low body weight you're going to want to fix

that by eating more food

an inhibitor for ghrelin includes stomach distension so

if you see over here on the diagram on the right distending the stomach is going to decrease ghrelin

and decrease appetite because you have a bunch of food in the stomach

and you don't eat anymore all right so let's hop over to leptin

so leptin is our satiety hormone and it is produced by our white fat

so these white adipose cells over here are going to produce our leptin

and as these cells go bigger and bigger and bigger they're going to produce more and more leptin.

So the fat is kind of doing a negative feedback on itself.

So fat produces more leptin.

This goes to the ventromedial hypothalamus.

Then we're going to get inhibition of food intake and the fats kind of get smaller.

So the fat is controlling itself in this case.

And an easy way to remember that leptin is produced by fat cells is

that I think of L for lipid and L for leptin and

inducers for leptin include insulin and emotional stress

so let's say you have high blood glucose you're going to have high insulin

and that's going to induce leptin say let's stop eating our blood sugar is high enough

and then emotional stress

so let's say you're running away from a tiger

you don't have time to think about those yummy blueberries in the bush

you're too busy devoting all your energy to fight or flight

so those are inducers for leptin so let's not be hungry in these cases.

And then inhibitors for leptin include short -term fasting.

So let's say you haven't eaten for eight, nine hours, your leptin response is going to be inhibited and ghrelin is going to take over.

So both ghrelin and leptin are in your system all the time, just the levels are different.

So sometimes ghrelin is higher and you're going to feel hungry and sometimes leptin is higher and you're going to feel satiated.

Let's talk about the hypothalamus for a second.

So these hormones are produced in the stomach and in the fat, and they're going to travel up to the hypothalamus,

and they're going to act either on the lateral or the medial hypothalamus.

So here in purple, we have the lateral hypothalamus, and here in blue, we have the medial hypothalamus.

So what does the lateral hypothalamus react to?

That's right, it's going to react to ghrelin, so it's going to cause you to be hungry.

Now in this case, the experimenters lesioned it, so they cut the lateral hypothalamus in these mice.

What's going to happen to this mouse?

Well it's going to get thinner because now our leptin is our predominant hormone

and it's telling the mouse I'm full all the time I don't need to eat

and ghrelin can no longer act on the lateral hypothalamus.

All right so let's say we lesion the ventromedial hypothalamus these two blue dots right here.

Well now ghrelin response is going to be more predominant

so our mouse is going to feel hungry all the time

and it's going to be fat

so we need a balance between these two hormones to get

our mouse just in the right weight range where it's not undernourished or overnourished.

An easy way to remember this is

that our lateral hypothalamus makes you grow laterally so

if we draw a guy over here let's say this is a skinny guy

and then this is a fatter version of himself so lateral hypothalamus makes you grow laterally

while the medial hypothalamus makes you grow medially, so you're going to get thinner.

Okay, so that's an easy way to remember this.

Okay, so let's do a little bit of a clinical correlate before we end off here, just to hammer the point home.

So here we have two obese people, but they're obese for different reasons.

Over here on the left, we have someone with Prater -Willi syndrome, which is a mutation on chromosome 15.

Now Prader -Willi does a bunch of things,

but one of the things it does in correspondence with ghrelin and leptin is that it increases ghrelin levels.

So now this man is going to feel hungry all the time and that's the cause for his obesity.

In contrast over here this small child has congenital obesity, so what that causes is an insensitivity to leptin.

So our medial hypothalamus right in here blue is no longer sensitive to leptin

which means this child does not feel satiated

at all so they're going to keep eating and eating

and eating so in both these people the ghrelin response is overactive in here

because they're on the right because there's more ghrelin

and on the left because there is an increase on decrease in leptin sensitivity

so ghrelin response is going to be more active in congenital obesity as well as Prader -Willi.

So that's often tested on boards just in case you want to remember these small facts.

All right, so I hope this video helped.

If you have any questions, please leave them in the comments, and I'll see you in the next one.

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이 레슨의 어휘와 말하기 포인트

이 말하기 레슨은 영상 “Appetite: Ghrelin and Leptin Explained”을(를) 바탕으로 합니다. 가장 자주 반복되는 단어는 다음과 같습니다: ghrelin, leptin, hypothalamus, lateral, fat. 이 영상에는 섀도잉할 문장 93개와 단어 1167개가 있습니다. 말하는 구간의 길이는 6:31입니다. 화자는 분당 약 179단어로, 일상 대화에 가까운 자연스러운 속도로 말합니다. 영어에서 가장 많이 쓰이는 3,000단어에 속하는 단어가 80%뿐이라 어휘가 어려운 편입니다.

이 영상의 핵심 어휘

영상에 나오는 익혀 둘 만한 단어 15개를 발음, 뜻과 함께 정리했습니다.

단어	발음	뜻
hormone 명사	/ˈhoɹmoʊn/	호르몬
stomach 명사	/ˈstʌmək/	위, 위장
hungry 형용사	/ˈhʌŋ.ɡɹi/	배고프다, 굶주리다
mouse 명사	/maʊs/	생쥐, 쥐
appetite 명사	/ˈæp.əˌtaɪt/	입맛, 식욕
thin 형용사	/ˈθɪn/	가늘다, 얇다
hunger 명사	/ˈhʌŋɡɚ/	굶주림, 배고픔
obesity 명사	/ə(ʊ)ˈbiːsɪti/	비만
react 동사	/ɹiːˈækt/	반응하다
skinny 형용사	/ˈskɪni/	마른, 빼빼한
insulin 명사	/ˈɪnsəlɪn/	인슐린
obese 형용사	/oʊˈbis/	뚱뚱한
sensitive 형용사	/ˈsɛn.sɪt.ɪv/	민감하다
acid 명사	/ˈæsɪd/	산
feedback 명사	/ˈfiːdˌbæk/	피드백, 비평

주의할 발음

화자는 you're, they're, don't 같은 축약형과 약화된 형태를 26번 사용합니다. 들리는 대로 짧게 발음하세요.

“sh”와 “zh” 소리: contrast /kənˈt(ʃ)ɹæst/, mutation /mjuˈteɪʃən/, lesion /ˈliːʒən/, satiate /ˈseɪʃɪeɪt/, distension /dɪsˈtɛnʃən/
긴 단어 — 강세 위치에 주의: obesity /ə(ʊ)ˈbiːsɪti/, sensitivity /ˌsɛn.səˈtɪv.ə.ti/, correspondence /ˌkoɹ.ɪˈspɑn.dəns/, congenital /kənˈdʒɛnɪt(ə)l/, inhibitor /ɪnˈhɪbɪtɚ/

한국어 화자가 어려워하는 소리:

/v/ — ㅂ(/b/)과 구별하기: sensitive /ˈsɛn.sɪt.ɪv/, sensitivity /ˌsɛn.səˈtɪv.ə.ti/, devote /dɪˈvəʊt/, overnourished /ˈoʊvɚnʌɹɪʃt/
/r/과 /l/ 구별하기: lateral /ˈlætəɹəl/, regulate /ˈɹɛɡ.jə.leɪt/, calorie /ˈkæləɹi/, ghrelin /ˈɡɹɛlɪn/, growl /ˈɡɹaʊ̯l/

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자신의 목소리를 녹음해 원본과 비교하고, hormone, stomach, hungry 같은 단어에 특히 주의합니다.

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쉐도잉 연습: Appetite: Ghrelin and Leptin Explained - 영상으로 영어 말하기 배우기

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