शैडोइंग अभ्यास: What is Narcolepsy? - वीडियो के साथ अंग्रेजी बोलना सीखें

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And how to kind of try to describe it to them.

I found over time it's really difficult for people to understand it.

It's just very complicated with this tiredness, the cataplexy, the fragmented sleep at night.

If you're a normal person, you've got sleep and you've got your waking life.

And occasionally they'll overlap a little bit.

For me, I live in this world that is very rarely am I fully awake and very rarely am I fully asleep.

I live in the in-between.

I'm Tom Scanlon.

I'm a professor of neurology at Harvard Medical School.

Narcolepsy is a neurologic disorder.

It is one of the most common sleep disorders.

It affects about one in two thousand people.

It doesn't matter how much sleep they get at night, they're going to feel sleepy every day.

People also can have a variety of other symptoms.

These include hypnagogic hallucinations, where they can have very vivid dreamlike hallucinations just as they're drifting off to sleep

or just when they awaken.

They can have something called sleep paralysis, where as they're falling asleep or sometimes when they wake up, they can't move.

And then there's cataplexy, which is similar to sleep paralysis.

The distinction is that cataplexy occurs right in the middle of the day, and it's triggered by strong emotions.

And then the last thing, which is perhaps sort of one of the strangest of all,

is that, considering that somebody with narcolepsy is often very sleepy through the day, they often have fragmented sleep at night.

They can wake up four or five times for 10 or 20 minutes for no clear reason.

And so in the same way that they have trouble maintaining wakefulness through the day, they they can have trouble maintaining sleep through the night.

Somewhere between age 10 and age 20 or so is when narcolepsy begins.

People usually start off with sleepiness and then the other symptoms follow.

So there's a number of different systems in the brain that are involved in promoting arousal or wakefulness and sleep.

Up here is the cortex.

This is the front near the forehead.

Here's the back.

This is the brainstem coming down here.

And this is the cerebellum, which is involved in balance.

The brainstem is the site that most of these arousal promoting signals come from.

And those cells send connections up throughout the whole front part of the brain,

and they help turn on the cortex and other parts of the brain when you're awake.

There's also some cells in a small region called the hypothalamus

that are involved in promoting sleep

and these sleep promoting cells one of the things they do is they actually turn off the wake promoting cells

and so that allows you to be fully asleep without any hint of consciousness.

This is called the mammillary body and just above it right here is where the hypocretin neurons sit.

And this is a really critical collection of neurons,

brain cells, that makes very particular and special neurotransmitters known as hypocretin or orexin.

Those are just two names for the same thing.

The hypocretin producing cells help activate and sustain activity in the other weight promoting brain regions across the day.

The brain contains billions of neurons and And only a very, very small number of these produce hypocretin.

It's probably somewhere between 100,000 and 200,000, which sounds like a large number, but when you compare it to 10 billion neurons, it's really very small.

In narcolepsy, those hypocretin-producing cells die off.

When you look closely at the brain of somebody who has narcolepsy, what you see is about a 90 to 95% loss of the hypocretin-producing neurons.

So there's two broad themes that are being pursued in narcolepsy research right now.

One theme is to understand what goes wrong in the brain when the hypocretin-producing cells die off.

How does that lead to sleepiness and cataplexing and other symptoms?

Another big theme is trying to understand what actually kills the hypocretin neurons in the first place.

Because if we could understand that, then it's possible that if one could diagnose and recognize narcolepsy right at the earliest stages,

we might be able to get in and stop that process.

As we've discovered more and more about what's actually causing the hypocretin neurons to die off,

and as we've discovered more about the consequences of that for the brain,

it's really given us a lot of hope for new opportunities for coming up with better therapies for people with narcolepsy.

If we could get hypocretin back in the brain somehow, that would be potentially as great is giving insulin to people with diabetes.

It would really be the missing factor coming back into play.

And it could, in theory, cure their sleepiness and cure their cataplexy in the most thorough fashion.

Right now, scientists are working with a variety of techniques to try to get hypocretin signaling back into the brain.

But the hope is that in 5, 10, or 15 years, we may see those hypocretin replacement therapies coming into clinical practice.

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अनुशंसित वीडियो

13 वाक्य

इस पाठ की शब्दावली और बोलने के सुझाव

यह स्पीकिंग पाठ वीडियो “What is Narcolepsy?” पर आधारित है। सबसे ज़्यादा दोहराए गए शब्द ये हैं: hypocretin, sleep, brain, narcolepsy, cells। इस वीडियो में शैडोइंग के लिए 61 वाक्य और 843 शब्द हैं। बोला गया हिस्सा 4:59 लंबा है। वक्ता लगभग 169 शब्द प्रति मिनट की स्वाभाविक गति से बोलता है, जो रोज़मर्रा की बातचीत के करीब है। 83% शब्द अंग्रेज़ी के 3,000 सबसे आम शब्दों में से हैं; बाकी शब्द अभ्यास से पहले देख लेना अच्छा रहेगा।

इस वीडियो की मुख्य शब्दावली

वीडियो के 15 सीखने लायक शब्द, उच्चारण और अर्थ के साथ:

शब्द	उच्चारण	अर्थ
symptom संज्ञा	/ˈsɪm(p)təm/	लक्षण, अलामत
discover क्रिया	/dɪˈskʌvə/	खोज निकालना, खोज करना
cure क्रिया	/kjɔː/	इलाज करना, उपचार करना
disorder संज्ञा	/dɪsˈɔɹdɚ/	अव्यवस्था, अस्त-व्यस्त
awake क्रिया	/əˈweɪk/	जागना
sleepy विशेषण	/ˈsliːpi/	उनींदा, निद्रालु
fragment संज्ञा	/ˈfɹæɡmənt/	अंश, खंड
complicated विशेषण	/ˈkɑm.plɪˌkeɪ.tɪd/	जटिल, पेचीदा
occur क्रिया	/əˈkɜː/	बीतना
technique संज्ञा	/tɛkˈniːk/	तकनीक
compare क्रिया	/kəmˈpɛɚ/	तौलना
scientist संज्ञा	/ˈsaɪəntəst/	वैज्ञानिक, आलिम
emotion संज्ञा	/ɪˈməʊ.ʃən/	भावना, जज़्बा
diabetes संज्ञा	/ˌdaɪəˈbiːtiːz/	मधुमेह
consciousness संज्ञा	/ˈkɑnʃəsnəs/	चेतना, होश

वीडियो में आने वाली फ़्रेज़ल वर्ब

शब्द	उच्चारण	अर्थ
wake up क्रिया	/ˌweɪk ˈʌp/	जागना
turn off क्रिया		बंद करना

इस वीडियो का व्याकरण

वक्ता जिन संरचनाओं का सबसे अधिक प्रयोग करता है, वीडियो के असली शब्दों के साथ:

संरचना	वीडियो में
Passive voice be + past participle — ज़ोर इस पर कि क्या होता है, न कि कौन करता है	are involved · is involved · is called
Relative clauses who / which + उपवाक्य — व्यक्ति या वस्तु के बारे में अतिरिक्त जानकारी	cataplexy, which is · thing, which is · cerebellum, which is
Present perfect have/has + past participle — बीता हुआ काम जिसका असर अभी भी है	have fragmented · we've discovered

ध्यान देने योग्य उच्चारण

वक्ता 14 बार संक्षिप्त रूपों का प्रयोग करता है, जैसे they're, I'm, we've। इन्हें वैसे ही छोटा बोलें जैसा आप सुनते हैं।

“sh” और “zh” की ध्वनियाँ: occasionally /əˈkeɪʒənəli/, potentially /pəˈtɛnʃ(ə)li/, emotion /ɪˈməʊ.ʃən/, consciousness /ˈkɑnʃəsnəs/, distinction /dɪˈstɪŋkʃən/
लंबे शब्द — बलाघात सही रखें: complicated /ˈkɑm.plɪˌkeɪ.tɪd/, occasionally /əˈkeɪʒənəli/, potentially /pəˈtɛnʃ(ə)li/, neurological /nɝəˈlɑd͡ʒɪkəl/, hypocretin /ˌhaɪ.poʊˈkɹiː.tən/

हिंदी भाषियों के लिए मुश्किल ध्वनियाँ:

/v/ और /w/ का फ़र्क़ — /v/ में ऊपर के दाँत निचले होंठ को छूते हैं, /w/ में होंठ गोल होते हैं: discover /dɪˈskʌvə/, awake /əˈweɪk/, consequence /ˈkɑn.sɪ.kwəns/, activate /ˈæktɪˌveɪt/, vivid /ˈvɪvɪd/
/z/ — इसे “ज” (/dʒ/) न बनाएँ: diabetes /ˌdaɪəˈbiːtiːz/, arousal /əˈɹaʊzəl/
/æ/ — “ऐ” से ज़्यादा खुला: fragment /ˈfɹæɡmənt/, activate /ˈæktɪˌveɪt/, overlap /ˌəʊvəˈlæp/, cataplexy /ˈkætəˌplɛksi/, paralysis /pəˈɹæləsəs/

इस वीडियो से अभ्यास कैसे करें

पहले बिना बोले पूरा वीडियो एक बार सुनें और जो शब्द नहीं आते उन्हें लिख लें।
0.75× गति से शुरू करें, एक-एक वाक्य की शैडोइंग करें, और सहज लगने पर सामान्य गति पर लौटें।
अपनी आवाज़ रिकॉर्ड करें और मूल से तुलना करें, ख़ासकर symptom, discover, cure जैसे शब्दों पर ध्यान दें।

शैडोइंग तकनीक क्या है?

शैडोइंग (Shadowing) एक विज्ञान-समर्थित भाषा सीखने की तकनीक है जो मूल रूप से पेशेवर दुभाषिया प्रशिक्षण के लिए विकसित की गई थी। विधि सरल लेकिन शक्तिशाली है: आप मूल अंग्रेज़ी ऑडियो सुनते हैं और तुरंत इसे ज़ोर से दोहराते हैं — जैसे वक्ता की छाया 1-2 सेकंड की देरी से। शोध से पता चलता है कि यह उच्चारण सटीकता, स्वर, लय, जुड़ी हुई ध्वनियाँ, सुनने की समझ और बोलने की प्रवाहशीलता में काफ़ी सुधार करता है।

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शैडोइंग अभ्यास: What is Narcolepsy? - वीडियो के साथ अंग्रेजी बोलना सीखें

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