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Many individuals suffering from the medical condition known as diabetes rely on artificial insulin to maintain good health.
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The principal means of delivering insulin to the body is via injection,
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but work is being done to develop other reliable means of administering it without having to use a syringe.
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Charlotte Newman reports.
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Diabetes is a condition in which the body does not release or properly respond to insulin, a hormone produced in the pancreas.
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Many diabetics require regular insulin injections to regulate their blood glucose levels, in some cases, as many as 10 or more shots a day.
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Although insulin injections allow diabetics to live full and active lives, the treatment does have inherent disadvantages.
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But at Syracuse University in New York, a new delivery method is currently under development.
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Insulin chewing gum.
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Chemist Max Garcia is here to tell us more.
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Well, while many diabetics inject themselves regularly without any real discomfort, some do experience pain and itching where the needle breaks the skin.
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A condition known as lipodystrophy in which the skin puckers can even develop at the site of multiple injections.
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At affected areas, the absorption of insulin may be impaired, making it difficult to calculate the correct dosage.
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Oral delivery of insulin would, therefore, be a preferable treatment.
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But the development of pills
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and capsules has been hampered by various problems relating to the physical and chemical stability of the hormone.
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One major challenge has been to find a way to protect insulin from the hostile conditions in the digestive system.
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Apparently, insulin molecules delivered by mouth will be broken down by the high acidity they encounter in the digestive tract.
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Scientists have tried various strategies to overcome this obstacle.
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And now the team at Syracuse has come up with a potential solution.
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That's right.
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Using their knowledge of the digestive system,
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our scientists realized that the body has a mechanism to protect valuable molecules as they pass through the digestive system.
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So the team decided to chemically bind insulin molecules to vitamin B12,
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A protein called haptocorin, present in the saliva in the mouth,
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joins with this particular vitamin to ensure its safe passage through the stomach to the intestine.
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The research team's idea was simply for the insulin to hitch a ride, as it were, along with a protected vitamin.
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This particular vitamin seems to be a very good choice once
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the b12 reaches the intestine intact another chemical takes over from the haptocorin to help it enter the bloodstream
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so by binding insulin to vitamin b12 the chances of it
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being absorbed into the bloodstream are optimized early tests with rats indicate
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that the researchers are on the right track in these tests the new treatment was administered in liquid form
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but chewing gum would probably be a more efficient medium for human beings.
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Through the chewing action, we could ensure sufficient haptocorin is produced.
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If this solution proves feasible and viable,
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diabetics might one day be able to throw away their syringes and reach for a pack of 1.
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What is one reason why researchers want to find an alternative delivery system for insulin?
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Number 2.
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What difficulty has impeded attempts to develop an oral insulin treatment?
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Number 3.
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What breakthrough did the chemists at Syracuse University make?
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Number 4.
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In which part of the body does haptocorin's protective function end?
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5. What is the current status of the research into chewing gum as a medium for insolent?
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Number 1.
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What is one reason why researchers want to find an alternative delivery system for insulin?
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Well, while many diabetics inject themselves regularly without any real discomfort, some do experience pain and itching where the needle breaks the skin.
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A condition known as lipodystrophy, in which the skin puckers can even develop at the site of multiple injections.
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Number 2.
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What difficulty has impeded attempts to develop an oral insulin treatment?
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Apparently, insulin molecules delivered by mouth will be broken down by the high acidity they encounter in the digestive tract.
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Scientists have tried various strategies to overcome this obstacle, and now the team at Syracuse has come up with a potential solution.
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Number three.
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What breakthrough did the chemists at Syracuse University make?
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that's right using their knowledge of the digestive system our scientists realized
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that the body has a mechanism to protect valuable molecules as they pass through the digestive system
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so the team decided to chemically bind insulin molecules to vitamin b12 a protein called haptocorin,
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present in the saliva in the mouth, joins with this particular vitamin to ensure its safe passage through the stomach to the intestine.
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Number 4.
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In which part of the body does haptocorin's protective function end?
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Once the B12 reaches the intestine intact, another chemical takes over from the haptocorin to help it enter the bloodstream.
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So by binding insulin to vitamin B12, the chances of it being absorbed into the bloodstream are optimized.
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Number 5.
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What is the current status of the research into chewing gum as a medium for insulin?
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Early tests with rats indicate that the researchers are on the right track.
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In these tests, the new treatment was administered in liquid form, but chewing gum would probably be a more efficient medium for human beings.
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Through the chewing action, we could ensure sufficient haptochorin is produced.

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Prática de IPADomine cada som
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Vídeo recomendado

Vocabulário e dicas de fala para esta lição

Esta aula de conversação usa o vídeo “TOEFL Listening Practice”. As palavras que mais se repetem: insulin, vitamin, digestive, chewing, molecules. Este vídeo tem 67 frases e 876 palavras para praticar shadowing. A fala dura 8:29. O falante fala devagar, cerca de 103 palavras por minuto, o que dá tempo para imitar cada som. Apenas 74% das palavras estão entre as 3.000 mais comuns do inglês, por isso o vocabulário é exigente.

Vocabulário principal deste vídeo

15 palavras do vídeo que vale a pena aprender, com pronúncia e significado:

PalavraPronúnciaSignificado
insulin substantivo/ˈɪnsəlɪn/insulina
vitamin substantivo/ˈvɪt.ə.mɪn/vitamina
chew verbo/tʃuː/mastigar, mascar
molecule substantivo/ˈmɑ.lɪ.kjul/molécula
injection substantivo/ɪnˈd͡ʒɛk.ʃən/injeção
scientist substantivo/ˈsaɪəntəst/cientista
researcher substantivo/ˈɹiˌsɝ.t͡ʃɚ/pesquisador, pesquisadora
oral adjetivo/ˈɔː.ɹəl/oral
administer verbo/ədˈmɪn.ɪ.stə/administrar
chemist substantivo/ˈkɛmɪst/químico, química
efficient adjetivo/ɪˈfɪʃənt/eficiente
stomach substantivo/ˈstʌmək/estômago
liquid substantivo/ˈlɪk.wɪd/líquido
indicate verbo/ˈɪndɪˌkeɪt/indicar
difficulty substantivo/ˈdɪfɪkəlti/dificuldade

Phrasal verbs que você vai ouvir

PalavraSignificado
come up with verbopensar (em), alcançar
throw away verbodeitar fora, jogar fora

Gramática neste vídeo

As estruturas que o falante mais usa, com as palavras exatas do vídeo:

EstruturaNo vídeo
Voz passiva be + particípio passado — o foco está no que acontece, não em quem fazbeing done · may be impaired · has been hampered
Present perfect have/has + particípio passado — uma ação passada que ainda importa agorahas been hampered · has been · have tried

Pronúncia para ficar de olho

  • Os sons de “sh” e “zh”: injection /ɪnˈd͡ʒɛk.ʃən/, efficient /ɪˈfɪʃənt/, sufficient /səˈfɪʃənt/, artificial /ˌɑː.tɪˈfɪʃ.əl/, absorption /æbˈsɔɹp.ʃn̩/
  • Palavras longas — acerte a sílaba tônica: administer /ədˈmɪn.ɪ.stə/, difficulty /ˈdɪfɪkəlti/, mechanism /ˈmɛk.ə.nɪ.zəm/, stability /stəˈbɪlɪti/, artificial /ˌɑː.tɪˈfɪʃ.əl/

Sons difíceis para falantes de português:

  • Consoante final — sem acrescentar um “i” depois: scientist /ˈsaɪəntəst/, bind /ˈbaɪ̯nd/, chemist /ˈkɛmɪst/, efficient /ɪˈfɪʃənt/, stomach /ˈstʌmək/
  • /l/ final — a língua toca o céu da boca, não vira “u”: molecule /ˈmɑ.lɪ.kjul/, oral /ˈɔː.ɹəl/, needle /ˈniː.dəl/, obstacle /ˈɑbstəkəl/, artificial /ˌɑː.tɪˈfɪʃ.əl/
  • /h/ — um sopro suave, diferente do “r”: hormone /ˈhoɹmoʊn/, hostile /ˈhɑstəl/, inherent /ɪnˈhɪəɹənt/, hamper /ˈhæm.pɚ/, hitch /hɪt͡ʃ/

Como praticar com este vídeo

  1. Ouça o vídeo inteiro uma vez sem falar e anote as palavras que você não conhece.
  2. Faça shadowing frase por frase na velocidade normal, repetindo cada uma até o seu ritmo ficar igual ao do falante.
  3. Grave a sua voz e compare com o original, prestando atenção a palavras como insulin, vitamin, chew.

O que é a Técnica de Shadowing?

Shadowing é uma técnica de aprendizado de idiomas com base científica, originalmente desenvolvida para o treinamento de intérpretes profissionais. O método é simples, mas poderoso: você ouve áudio em inglês nativo e repete imediatamente em voz alta — como uma sombra seguindo o falante com 1-2 segundos de atraso. Pesquisas mostram melhora significativa na precisão da pronúncia, entonação, ritmo, sons conectados, compreensão auditiva e fluência na fala.

Técnica de shadowing: leia o guia completo passo a passo →